Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Ilse KrebsSusanne Binder

Abstract

To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1-3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1+/-7.9 (55-89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4-6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8-10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a le...Continue Reading

References

Aug 23, 2005·The British Journal of Ophthalmology·I KrebsA Goll
Feb 7, 2006·Ophthalmology·Robert L AveryMatthew J Giust
Jul 4, 2006·American Journal of Ophthalmology·Ziad F BashshurBaha' N Noureddin

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Citations

May 25, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eva SmretschnigSusanne Binder
May 15, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Elisabetta PilottoEdoardo Midena
Aug 21, 2014·British Medical Bulletin·Tomas IlginisPraveen J Patel
Aug 18, 2012·Survey of Ophthalmology·Pearse A KeaneAdnan Tufail
Jun 3, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Ilse KrebsSusanne Binder
Jun 6, 2015·International Ophthalmology·Asima BajwaAshvini K Reddy

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