PMID: 9421724Jan 9, 1998Paper

Activity of pentamidine-loaded methacrylate nanoparticles against Leishmania infantum in a mouse model

International Journal for Parasitology
R DurandM Deniau

Abstract

The use of drug delivery systems may reduce the toxicity and improve the activity of antileishmanial compounds. In view of such a strategy, we loaded the antileishmanial agent pentamidine on polymethacrylate nanoparticles. The activity of pentamidine-loaded nanoparticles was compared with that of free pentamidine in a BALB/c mice model of visceral leishmaniasis induced by Leishmania infantum. On day 0, mice were infected intravenously with 10(7) promastigotes and then treated via the tail vein on days 14, 16 and 18 with bound pentamidine, free drug or isotonic saline (control group). On day 21, liver parasite burdens were evaluated using the Stauber method. Livers and spleens were removed and weighed. Effective doses (ED) were determined using the Michaelis-Menten representation relating the percentage of parasite suppression to the dose. The ED50 of bound pentamidine was six times lower than that of free pentamidine (0.17 mg kg-1 vs 1.06 mg kg-1). The ED90 value calculated for bound pentamidine was 1 mg kg-1. It was not possible to obtain the ED90 for free pentamidine because the dose-response curve reached a plateau near 60% of parasite suppression. A significant decrease in liver and spleen weights, probably reflecting the l...Continue Reading

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Citations

Jun 17, 2000·International Journal for Parasitology·E CauchetierM Deniau
Mar 15, 2011·Immunotherapy·Francois Fay, Christopher J Scott
Oct 23, 2013·Future Medicinal Chemistry·Masoom YasinzaiGul Shahnaz
Sep 14, 2004·Tropical Medicine & International Health : TM & IH·M A Dea-AyuelaF Bolás-Fernández
Jul 14, 2012·Journal of Parasitology Research·Saied SoflaeiMohsen Shafiepour
Jun 14, 2003·Annals of Tropical Medicine and Parasitology·E CauchetierM Deniau
Oct 24, 2013·Expert Opinion on Drug Delivery·Shalini AsthanaManish K Chourasia
Jul 2, 2008·Expert Opinion on Drug Delivery·Eder L Romero, Maria Jose Morilla
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Elizandra Aparecida BrittaRedouane Borsali
May 20, 2011·Expert Opinion on Drug Delivery·Maya KroubiDidier Betbeder
Mar 6, 2010·Expert Opinion on Drug Delivery·Swati GuptaSuresh P Vyas
Jun 26, 2015·PLoS Pathogens·Juan D Unciti-BrocetaJosé A Garcia-Salcedo
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·S BretagneM Deniau
Sep 5, 2017·International Journal of Biological Macromolecules·Jaleh VarshosazMahdi Delavari
Apr 17, 2009·International Journal of Antimicrobial Agents·Sandra Elisa HaasTeresa Dalla Costa

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