PMID: 10471549Sep 3, 1999Paper

Activity of pleconaril against enteroviruses

Antimicrobial Agents and Chemotherapy
Daniel C PevearJ M Groarke


The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly isolated enterovirus serotypes was examined. The latter viruses were isolated by the Centers for Disease Control and Prevention during the 1970s and 1980s from clinically ill subjects. Pleconaril at a concentration of </=0.03 microM inhibited the replication of 50% of all clinical isolates tested. Ninety percent of the isolates were inhibited at a drug concentration of </=0.18 microM. The most sensitive serotype, echovirus serotype 11, was also the most prevalent enterovirus in the United States from 1970 to 1983. Pleconaril was further tested for oral activity in three animal models of lethal enterovirus infection: coxsackievirus serotype A9 infection in suckling mice, coxsackievirus serotype A21 strain Kenny infection in weanling mice, and coxsackievirus serotype B3 strain M infection in adult mice. Treatment with pleconaril increased the survival rate in all three models for both prophylactic and therapeutic dosing regimens. Moreover, pleconaril dramatically reduced virus levels in target tissues of coxsackievirus serotype B3 strain M-infected animals. Pleconaril represents a promising new drug can...Continue Reading


Jan 1, 1979·Journal of Medical Virology·C GaunttT Nealon
Jan 1, 1992·Annual Review of Microbiology·Mark McKinlayMichael G Rossmann
Nov 27, 1992·Journal of Medicinal Chemistry·T R BaileyDaniel C Pevear
May 1, 1990·Journal of Medicinal Chemistry·G D DianaF J Dutko
Nov 5, 1989·Journal of Molecular Biology·S S KimMark McKinlay
Dec 1, 1989·Antimicrobial Agents and Chemotherapy·M G WoodsMark McKinlay
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J BadgerMichael G Rossmann
Jun 1, 1985·Antimicrobial Agents and Chemotherapy·M J OttoMark McKinlay
Feb 1, 1986·The Journal of Infectious Diseases·R A StrikasR A Parker
Feb 1, 1987·Antiviral Research·M T KennyJ K Daniel
Mar 1, 1987·Reviews of Infectious Diseases·R E McKinneyC M Wilfert
Dec 8, 1995·Journal of Molecular Biology·D K Phelps, C B Post
Jul 7, 1995·Journal of Medicinal Chemistry·J W GuilesDaniel C Pevear
Mar 1, 1995·Journal of Clinical Microbiology·P HalonenMark A Pallansch
Oct 29, 1993·Journal of Medicinal Chemistry·G D DianaV Giranda
Oct 1, 1993·The Pediatric Infectious Disease Journal·M J AbzugH A Rotbart
Mar 5, 1993·Journal of Molecular Biology·K H KimG D Diana
Jul 15, 1995·Structure·J K MuckelbauerMichael G Rossmann
Feb 1, 1996·Brain : a Journal of Neurology·P RudgeN Hyman
Jan 1, 1997·The Pediatric Infectious Disease Journal·A S ChidekelA R Bazzy
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K LewisG Siuzdak
Jul 1, 1998·Clinical and Diagnostic Virology·J O Kim, R L Hodinka
May 6, 1999·The Journal of Infectious Diseases·J M Groarke, Daniel C Pevear
Jun 4, 1999·Journal of Clinical Pharmacology·S M Abdel-Rahman, G L Kearns


Dec 23, 1999·The Pediatric Infectious Disease Journal·M H Sawyer
May 23, 2000·Annals of Medicine·T Heikkinen, T Chonmaitree
Feb 15, 2001·Current Opinion in Pediatrics·M H Sawyer
Jul 20, 2002·Current Infectious Disease Reports·José R. Romero
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick G HaydenPleconaril Respiratory Infection Study Group
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Shin-Ru ShihYu-Sheng Chao
Aug 13, 2004·Proceedings. Biological Sciences·Dominik Wodarz, Alun L Lloyd
Oct 14, 2004·The Journal of Perinatal & Neonatal Nursing·Galina BarfordRoger G Faix
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·R A DesmondR J Whitley
Jan 16, 2008·Journal of Biomedical Science·Tzu-Chun ChenShin-Ru Shih
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Oct 31, 2008·The Journal of Infectious Diseases·Ashley L FowlkesNino Khetsuriani
Aug 29, 2009·Medicinal Research Reviews·Judith M Rollinger, Michaela Schmidtke
Nov 8, 2012·Korean journal of pediatrics·Kwi Sung ParkJoon Soo Park
Nov 15, 2014·The Journal of General Virology·Kimberley S M BenschopKatja C Wolthers
Jul 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanhong WeiShaoyong Ke
Sep 10, 2014·Antimicrobial Agents and Chemotherapy·Aloys TijsmaJohan Neyts
May 21, 2015·Journal of Intensive Care Medicine·Christopher NguyenJuliana Barr
Nov 5, 2015·Expert Review of Respiratory Medicine·Nicola Principi, Susanna Esposito
Oct 7, 2015·Nanoscale·Mari MartikainenVarpu Marjomäki
Mar 20, 2018·PLoS Pathogens·Majid LaassriLester Shulman
Mar 11, 2018·Biochemistry. Biokhimii︠a︡·O S NikonovE Yu Nikonova
Apr 8, 2018·Nature Reviews. Microbiology·Jim BaggenFrank J M van Kuppeveld
Jan 12, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Adriana BraunovaMichal Kyr
Jan 1, 2020·Virusdisease·Sarkar SoumajitVeerakyathappa Bhanuprakash
Dec 23, 2003·Bone Marrow Transplantation·S ChakrabartiD W Milligan
May 3, 2001·The Pediatric Infectious Disease Journal·E AradottirS T Shulman
May 25, 2004·Antimicrobial Agents and Chemotherapy·Anna L SalvatiLucia Fiore
Jan 11, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S Fujioka, Y Kitaura
Apr 20, 2002·Current Opinion in Infectious Diseases·Andrew J. Pollard, Simon R. Dobson
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I SteinerP G E Kennedy
Mar 4, 2005·The Journal of Antimicrobial Chemotherapy·Vadim A MakarovMichaela Schmidtke
Jul 29, 2009·Antimicrobial Agents and Chemotherapy·M Steven ObersteMarc S Collett
Aug 18, 2009·Expert Review of Anti-infective Therapy·Shih-Min Wang, Ching-Chuan Liu
Apr 28, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuela LaconiRaffaello Pompei
Jun 10, 2011·Critical Reviews in Microbiology·Lina YiMing-Liang He

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