Activity of proximal promoter of the human beta(1)-integrin gene was increased in Sézary syndrome

Leukemia Research
Y PaulinM Aubery

Abstract

Changes in beta1-integrin expression have been involved in abnormal cellular interactions between malignant lymphocytes from Sézary (Sz) patients and keratinocytes. In this paper, we compare the activity of both distal and proximal promoters of the beta1-integrin gene in malignant lymphocytes from Sz patients with human normal lymphocytes. Activity of both beta1-integrin promoters was also analysed in human normal keratinocytes. Northern blot analysis shows that beta1-integrin mRNA expression is higher in malignant Sz lymphocytes than in normal lymphocytes. CAT assays show that the activity of proximal beta1-integrin promoter is markedly increased (up to 6-fold) in malignant lymphocytes from Sz patients, in comparison to normal lymphocytes. These results suggest that changes in activity of the proximal promoter of beta1-integrin subunit could be, in part, responsible for the abnormal cellular interactions between malignant lymphocytes and keratinocytes observed in Sz syndrome.

References

Aug 1, 1992·The Journal of Investigative Dermatology·P SavoiaM G Bernengo
Apr 21, 1989·JAMA : the Journal of the American Medical Association·B J NickoloffK D Cooper
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J PriceC Cepko
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Dec 1, 1993·Cell Adhesion and Communication·E HirschF Altruda
Sep 5, 1998·Trends in Cell Biology·P E Hughes, M Pfaff
Oct 9, 1998·The Journal of Investigative Dermatology·M BoukhelifaF Braut-Boucher
Dec 5, 1998·The Journal of Biological Chemistry·A S TakaokaS Hirohashi
Mar 16, 2013·Mayo Clinic Proceedings·Barry Ladizinski, Elise A Olsen

❮ Previous
Next ❯

Citations

Oct 31, 2003·The Journal of Biological Chemistry·Loredana MoroMargherita Greco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.