Dec 21, 2011

Activity of pyocin S2 against Pseudomonas aeruginosa biofilms

Antimicrobial Agents and Chemotherapy
Karen SmithDaniel Walker

Abstract

In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.

  • References12
  • Citations18

References

  • References12
  • Citations18

Citations

Mentioned in this Paper

Pseudomonas aeruginosa (antigen)
Azactam
Lung
Infectious Disease of Lung
Respiratory Physiology
Sputum, Induced
Cystic Fibrosis
Pulmonary Function Tests
Antheraea
Pseudomonas aeruginosa

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