Activity of retapamulin against Streptococcus pyogenes and Staphylococcus aureus evaluated by agar dilution, microdilution, E-test, and disk diffusion methodologies.

Antimicrobial Agents and Chemotherapy
Glenn A PankuchP C Appelbaum

Abstract

The in vitro activity of retapamulin against 106 Staphylococcus aureus isolates and 109 Streptococcus pyogenes isolates was evaluated by the agar dilution, broth microdilution, E-test, and disk diffusion methodologies. Where possible, the tests were performed by using the CLSI methodology. The results of agar dilution, broth microdilution, and E-test (all with incubation in ambient air) for S. aureus yielded similar MICs, in the range of 0.03 to 0.25 microg/ml. These values corresponded to zone diameters between 25 and 33 mm by the use of a 2-microg retapamulin disk. Overall, 99% of the agar dilution results and 95% of E-test results for S. aureus were within +/-1 dilution of the microdilution results. For S. pyogenes, the MICs obtained by the agar and broth microdilution methods (both after incubation in ambient air) were in the range of 0.008 to 0.03 microg/ml, and E-test MICs (with incubation in ambient air) were 0.016 to 0.06 microg/ml. For S. pyogenes, 100% of the agar dilution MIC results were within +/-1 dilution of the broth microdilution results. E-test MICs (after incubation in ambient air) were within +/-1 and +/-2 dilutions of the broth microdilution results for 76% and 99% of the isolates, respectively. E-test MICs...Continue Reading

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Citations

Jun 15, 2007·Antimicrobial Agents and Chemotherapy·W Scott Champney, Ward K Rodgers
Feb 24, 2011·Antimicrobial Agents and Chemotherapy·Emilio Pérez-TralleroVictor Iriarte
Sep 22, 2009·Applied and Environmental Microbiology·Sreedhar KilaruGary D Foster
May 14, 2009·Therapeutics and Clinical Risk Management·Ribhi ShawarHarmony Garges
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Chen DavidovichAda Yonath
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Mar 4, 2021·The Pediatric Infectious Disease Journal·Ami B PatelBo Shopsin

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