Activity of the enzymes participating in purine metabolism of cancerous and noncancerous human kidney tissues

Cancer Investigation
I DurakS Ulutepe

Abstract

In this study, activity of some of the key enzymes participating in purine metabolism was measured in cancerous and noncancerous human kidney tissues from 18 patients with renal cell carcinoma. Twelve cancerous tissues were at stage T1-T2 and 6 tissues were at stage T3-T4. Adenosine deaminase (ADA) and guanase (GUA) activity was increased and xanthine oxidase (XO) activity decreased in cancerous tissues compared to noncancerous ones. No difference was, however, found between 5'-Nucleotidase (5'-NT) activity of the tissues. There were also no statistically meaningful differences between the enzyme activities of the cancerous tissues at stage T1-2 and T3-4. Results suggest that the changes observed in the activity of the enzymes participating in purine metabolism result from accelerated DNA turnover in the cancerous tissues and cells, and these changes might provide selective advantage, possibly by causing acceleration of salvage pathway activity, to the cancer cells to grow and develop more rapidly.

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Citations

Sep 29, 2000·Pharmacology & Therapeutics·J Spychala
Nov 6, 2014·Electromagnetic Biology and Medicine·Zahide Esra DurakBahadır Öztürk
Jul 22, 2011·Critical Reviews in Biotechnology·Amit AgarwalU C Banerjee
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Sep 25, 2019·Cancers·Marcella CamiciMaria Grazia Tozzi
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joon Min JungSung Eun Chang
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Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nina LinderHeikki Joensuu
Mar 31, 2007·The Journal of Physical Chemistry. B·Lishan YaoHonggao Yan

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