Activity of the essential oil from Chenopodium ambrosioides grown in Cuba against Leishmania amazonensis

Chemotherapy
Lianet MonzoteJuan Abreu

Abstract

Current therapy against leishmaniasis is unsatisfactory. Efficacious and safe new drugs are needed. In this study, we show the leishmanicidal effect of an essential oil from Chenopodium ambrosioides against Leishmania amazonensis. The tested product had a potent inhibitory action against promastigote and amastigote forms, with 50% effective dose values of 3.7 and 4.6 microg/ml, respectively. The essential oil showed a moderate toxicity on macrophages from BALB/c mice. An optimal dose of 30 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally. These studies revealed a potential source for the discovery of novel drugs to combat the leishmaniasis based on the traditional medicine.

References

Oct 1, 1995·The Journal of Infectious Diseases·A L BodleyT A Shapiro
Mar 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L CroftD B Herrmann
Jan 4, 1993·Journal of Immunological Methods·D SladowskiM Balls
May 1, 1996·Revista Da Sociedade Brasileira De Medicina Tropical·F FrançaP D Marsden
Dec 1, 1995·Acta Tropica·S A Da SilvaB Rossi-Bergmann
May 1, 1999·Antimicrobial Agents and Chemotherapy·E C Torres-SantosB Rossi-Bergmann
Aug 5, 2000·Journal of Natural Products·A A Ahmed
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·J C DelorenziE M Saraiva
Aug 9, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Desjeux
Apr 27, 2002·Journal of Natural Products·Fumiyuki KiuchiTakashi Aoki
Jun 29, 2002·The Journal of Infectious Diseases·Noris RodriguezRoberto Docampo
Aug 8, 2002·The American Journal of Tropical Medicine and Hygiene·Jiaxiang JiLynn Soong
Oct 23, 2002·Tropical Medicine & International Health : TM & IH·M BoelaertP Van Der Stuyft
May 10, 2003·Journal of Ethnopharmacology·Manuel Jesús Chan-BacabLuis Manuel Peña-Rodríguez

❮ Previous
Next ❯

Citations

Feb 17, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Valery DembitskyLumir Ondrej Hanus
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Klinger Antonio da Franca RodriguesFernando Aécio de Amorim Carvalho
Dec 23, 2009·Journal of Ethnopharmacology·Wanderson S PereiraFlávia R F Nascimento
Dec 3, 2014·Journal of Ethnopharmacology·Klinger Antonio da Franca RodriguesFernando Aécio de Amorim Carvalho
Aug 30, 2008·Trends in Parasitology·Lázara Rojas RiveroLucy J Robertson
Nov 24, 2007·Journal of Ethnopharmacology·Fernando J PatrícioFlávia R F Nascimento
Nov 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F BakkaliM Idaomar
Jul 10, 2007·European Journal of Medicinal Chemistry·Valery M Dembitsky
Mar 16, 2007·Fitoterapia·Claudio M Lezama-DávilaLaritza Hernández-Rivero
Aug 29, 2007·Phytotherapy Research : PTR·L MonzoteJ Abreu
Nov 19, 2013·Chemistry & Biodiversity·Hidayat HussainIftikhar Ali
Apr 25, 2012·ISRN Pharmacology·Marley GarcíaPedro Herrera
Aug 16, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Aline Cavalcanti De QueirozMagna Suzana Alexandre-Moreira
Dec 17, 2014·Frontiers in Microbiology·Mohammad IslamuddinFarhat Afrin
Aug 6, 2016·Parasitology Research·Dalila Nunes CysneFlávia Raquel Fernandes Nascimento
Mar 22, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sonali SinhaAnita Mukherjee
Apr 30, 2010·Memórias do Instituto Oswaldo Cruz·Lianet MonzoteMigdalia Miranda
Jan 13, 2011·Memórias do Instituto Oswaldo Cruz·Josiane Cardoso, Maurilio José Soares
Sep 8, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Lianet MonzoteJuan Abreu
Mar 7, 2017·Biochemical Pharmacology·Gerald GeroldingerLars Gille
Nov 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vera A Vil'Alexander O Terent'ev
Oct 22, 2011·Asian Pacific Journal of Tropical Medicine·Marley GarcíaLianet Monzote
Jul 4, 2019·Revista Do Instituto De Medicina Tropical De São Paulo·Raquel Regina Duarte MoreiraCelso Vataru Nakamura
Aug 25, 2010·Pharmaceutical Biology·Marley GarcíaRamón Scull
Jan 9, 2015·PLoS Neglected Tropical Diseases·Mohammad IslamuddinFarhat Afrin
Aug 4, 2020·Parasitology·Célia Eliane de Lara da SilvaMaria Valdrinez Campana Lonardoni
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Emanuela Coutinho LunaFrancisco Jaime Bezerra Mendonça
Jul 6, 2021·Frontiers in Pharmacology·Luiz Felipe D PasseroEliana Rodrigues
Jul 24, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Elham ZarenezhadMahmoud Osanloo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.