Activity of the medial prefrontal cortex and amygdala underlies one-trial tolerance of rats in the elevated plus-maze

Journal of Neuroscience Methods
Lucas Albrechet-SouzaM L Brandão

Abstract

The anxiolytic effects of benzodiazepines are reduced after a single exposure of rats to elevated plus-maze test (EPM). Midazolam showed an anxioselective profile in animals submitted to one session (T1) but did not change the usual exploratory behavior of rats exposed twice (T2) to the EPM. In this study we examined further the one-trial tolerance by performing a factor analysis of the exploratory behavior of rats injected with saline before both trials as well as an immunohistochemistry study for quantification of Fos expression in encephalic structures after these sessions. Factor analysis of all behavioral categories revealed that factor 1 consisted of anxiety-related categories in T1 whereas these same behavioral categories loaded on factor 2 in T2. Risk assessment was also dissociated as it loaded stronger on T2 (factor 3) than on T1 (factor 4). Locomotor activity in T1 loaded on factor 5. Immunohistochemistry analyses showed that Fos expression predominated in limbic structures in T1 group. The medial prefrontal cortex and amygdala were the main areas activated in T2 group. These data suggest that anxiety and risk assessment behaviors change their valence across the EPM sessions. T2 is characterized by the emergence of a...Continue Reading

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Citations

Dec 24, 2011·Psychopharmacology·Kwok Ho C ChoyDmitry N Mayorov
Jun 17, 2014·Pharmacology, Biochemistry, and Behavior·Aslıhan SayinHayrunnisa Bolay
Oct 14, 2011·Stress : the International Journal on the Biology of Stress·Fernando M C V ReisMarcus L Brandão
May 15, 2013·Journal of Neuroscience Methods·Rafael ArantesAntonio C Roque
Aug 9, 2011·Behavioural Brain Research·Adam J DevallThelma A Lovick
Jul 25, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·K S Gomes, R L Nunes-De-Souza
Jul 6, 2015·Behavioural Brain Research·Adriano Edgar ReimerMarcus Lira Brandão
Jun 19, 2013·Journal of Ethnopharmacology·Hirotaka Shoji, Kazushige Mizoguchi
Feb 19, 2014·Physiology & Behavior·Mohammad NasehiMohammad-Reza Zarrindast
Sep 12, 2012·The International Journal of Neuropsychopharmacology·Lucas Albrechet-SouzaMarcus Lira Brandão
Sep 21, 2018·Behavior Genetics·Lucía Raily AcuñaGeison Souza Izídio
May 26, 2017·Anais Da Academia Brasileira De Ciências·Ricardo M BassettoRegina C Spadari

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