Jul 1, 1977

Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens

Agents and Actions
I KarakozK Hála

Abstract

Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment.

Mentioned in this Paper

Immune Response
Mercaptopurine
Cyclophosphamide
Variolation
Decreased Immunologic Activity [PE]
Inbred Strain
Purified Protein Derivative of Tuberculin
Antibody Formation
Cellular Infiltration
Hybrids

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