Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children's Oncology Group AREN0321 Study.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Najat C DawAREN0321 Study Committee

Abstract

AREN0321 evaluated the activity of vincristine and irinotecan (VI) in patients with newly diagnosed diffuse anaplastic Wilms tumor (DAWT) and whether a regimen containing carboplatin (regimen UH1) in addition to regimen I agents used in the National Wilms Tumor Study 5 (NWTS-5; vincristine, doxorubicin, cyclophosphamide, and etoposide plus radiotherapy) would improve patient outcomes. Patients with stage II to IV DAWT without measurable disease received regimen UH1. Patients with stage IV measurable disease were eligible to receive VI (vincristine, 1.5 mg/m2 per day intravenously on days 1 and 8; irinotecan, 20 mg/m2 per day intravenously on days 1-5 and 8-12 of a 21-day cycle) in an upfront window; those with complete (CR) or partial response (PR) had VI incorporated into regimen UH1 (regimen UH2). The study was designed to detect improvement in outcomes of patients with stage II to IV DAWT compared with historical controls treated with regimen I. Sixty-six eligible patients were enrolled. Of 14 patients with stage IV measurable disease who received VI, 11 (79%) achieved CR (n = 1) or PR (n = 10) after 2 cycles. Doses of doxorubicin, cyclophosphamide, and etoposide were reduced midstudy because of nonhematologic toxicity. Four...Continue Reading

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Citations

Dec 21, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jesper BrokFilippo Spreafico
Jan 5, 2021·Current Opinion in Pediatrics·Marie V NelsonJeffrey S Dome
Feb 17, 2021·Current Oncology Reports·Juhi JainAndrew L Hong
Jul 3, 2021·Cancers·Alissa GroenendijkAnnelies M C Mavinkurve-Groothuis
Aug 21, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Jeffrey S DomeConrad V Fernandez
Aug 21, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Frank BalisMiranda Hughes
Oct 16, 2021·Nature Reviews. Disease Primers·Filippo SpreaficoKathy Pritchard-Jones
Oct 26, 2021·Pediatric Blood & Cancer·Andrew D WoodsCharles Keller

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