PMID: 9434850Jan 22, 1998Paper

Activity profiles of carcinogenicity data: application in hazard identification and risk assessment

Mutation Research
M A JacksonM D Waters

Abstract

Animal cancer data play a primary role in human risk assessment due to the limited epidemiological data. The current database of test results from the NCI/NTP rodent bioassays provide valuable information concerning the carcinogenic potential of hundreds of environmental agents. An approach is presented to reduce and graphically display these data as activity profiles to allow visualization and assessment of tumor response trends across multiple parameters, e.g. species, sex, target site, and route of exposure. Spreadsheet graphics are used to construct the profiles organized on the multiple parameters of carcinogenicity in a format that enables comparative analysis among chemicals. Several example applications are described to illustrate the value of activity profiles in hazard identification and risk assessment. The NCI/NTP data used in developing this concept are from the Carcinogen Potency Database (CPDB) complied by Gold et al. (Environ. Health Perspect. 103 (Suppl. 8) (1995) 3-122). Computer links to the underlying details in the CPDB are maintained such that specific histopathologies at individual tumor sites, duration of the study, dose-response data, and notes related to diet, survival, treatments, and the authors eval...Continue Reading

References

Dec 1, 1991·Environmental Health Perspectives·M D WatersM A Jackson
Dec 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·D Wartenberg, M A Gallo
Dec 1, 1987·Risk Analysis : an Official Publication of the Society for Risk Analysis·C J Portier, D G Hoel
Apr 17, 1987·Science·B N AmesL S Gold
Dec 1, 1984·Environmental Health Perspectives·L S GoldR Peto
Oct 1, 1994·Chemico-biological Interactions·M LågE J Søderlund
Aug 1, 1993·Risk Analysis : an Official Publication of the Society for Risk Analysis·D KrewskiM Szyszkowicz
Apr 1, 1993·Risk Analysis : an Official Publication of the Society for Risk Analysis·D W GaylorD M Sheehan

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Citations

Oct 22, 2008·Regulatory Toxicology and Pharmacology : RTP·Gary M Williams, Michael J Iatropoulos
Aug 5, 2008·Toxicology and Applied Pharmacology·Michael Waters, Marcus Jackson

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