Activity-stress increases density of GFAP-immunoreactive astrocytes in the rat hippocampus

Stress : the International Journal on the Biology of Stress
K G LambertC H Kinsley

Abstract

Although past research has indicated that stress and the accompanying increase in glucocorticoids compromises hippocampal neurons, little is known about the effect of stress on hippocampal glial cells. In the current study, male rats were exposed to activity-stress (A-S) for six days; this comprised housing with an activity wheel and restricted access (1h/day) to food. Physiological data (e.g., relative adrenal and thymus weights, gastric ulceration) suggested that the A-S rats experienced more stress than pair-fed (no wheel) and control (fed ad libitum, no wheel) rats. Whereas stress did not influence the quantitative morphology of glial fibrillary acidic protein (GFAP)-immunoreactive cells, a semi-quantitative analysis revealed that the A-S rats had significantly more (30%) GFAP-immunoreactive cells in the hippocampal CA3 region than the control rats. Based on the present findings, it appears that the hippocampal astrocytic response to chronic stress may be similar to the response found in endangered, or challenged hippocampal environments, such as in ischemia.

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Citations

Jun 10, 2006·Cellular and Molecular Neurobiology·Nashat AbumariaGabriele Flügge
Jun 30, 2006·Cellular and Molecular Neurobiology·Flavia E SaraviaAlejandro F De Nicola
Apr 5, 2003·Physiology & Behavior·Thomas CampbellKelly Lambert
Sep 12, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yanina RevsinMelly S Oitzl
Mar 2, 2012·BMC Neuroscience·Marina Negrão Frota de AlmeidaMarcia Consentino Kronka Sosthenes
Dec 10, 2013·Acta Neuropathologica·Paul J LucassenBoldizsár Czéh
Jan 23, 2016·Frontiers in Integrative Neuroscience·Jiah Pearson-LearyEwan C McNay
Dec 15, 2015·The International Journal of Neuropsychopharmacology·Matteo M PuscedduTimothy G Dinan
Sep 18, 2012·Journal of Pharmacological and Toxicological Methods·Blase BillackCraig H Kinsley
Dec 22, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nashat AbumariaGabriele Flügge
Jun 10, 2010·Molecular Systems Biology·Hani GoodarziSaeed Tavazoie
Dec 19, 2019·Frontiers in Neuroscience·Ann Katrin Sauer, Andreas M Grabrucker
Aug 28, 2018·AIMS Neuroscience·Pranav Chintamani Joshi, Sugato Benerjee

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