Activity-wheel stress and serotonergic hypersensitivity in rats.

Pharmacology, Biochemistry, and Behavior
A R MayedaM H Aprison

Abstract

Adult male Wistar rats were subjected to activity wheel stress: unlimited access to an activity wheel for up to twelve days and food for 30 to 60 min each day. Each treated rat was paired with a control, the latter being housed in home cages and given sufficient food to maintain a weight similar to the stressed partner. All rats were previously trained on a variable interval schedule for milk reinforcement. When the activity of the stressed rat increased rapidly then decreased suddenly, the pair was decapitated for biochemical analysis. Levels of the serotonin metabolite, 5-hydroxyindoleacetic acid, decreased by 50%, and the Bmax for ketanserin binding increased by 19% in frontal cortical homogenates from the stressed rats when compared to controls. These data support the concept that stress increases the sensitivity of central serotonin receptors.

References

Jun 1, 1979·Journal of Neurochemistry·L N FleisherM H Aprison
Dec 1, 1987·Journal of Neurochemistry·B L RothD M Chuang
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·K L BruggeM H Aprison
Jun 1, 1980·Pharmacology, Biochemistry, and Behavior·C C LoullisM H Aprison
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·H NagayamaM H Aprison
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·H NagayamaM H Aprison
Jan 1, 1980·Brain Research Bulletin·W P Paré
Dec 17, 1981·European Journal of Pharmacology·M A BlackshearE Sanders-Bush
Aug 29, 1980·European Journal of Pharmacology·P SeemanJ J Warsh

❮ Previous
Next ❯

Citations

May 1, 1991·Pharmacology, Biochemistry, and Behavior·M N SpigelmanG E Rockman
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·W K ParkM H Aprison
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·J AkiyoshiH Nagayama
Jan 1, 1990·Annals of the New York Academy of Sciences·A Tsuda, M Tanaka
May 12, 2007·Pharmacology, Biochemistry, and Behavior·Fumikazu YokoyamaTaiichiro Imanishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.