Actual Versus Expected Doses of Half Tablets Containing Prescribed Psychoactive Substances: A Systematic Review

The Primary Care Companion to CNS Disorders
Jaqueline K EserianJosé C F Galduróz

Abstract

To assess through a systematic review of the literature if the practice of splitting tablets containing psychoactive/psychotropic medications for medical or economic reasons would result in the expected doses. A MEDLINE and PsycInfo comprehensive search of English-language publications from January 1999 to December 2015 was conducted using the terms describing tablet splitting (tablet splitting, split tablets, tablet subdivision, divided tablets, and half tablets) and psychoactive substances (psychoactive medicines, psychotropic medicines, antidepressants, anxiolytics, anticonvulsants, antipsychotics, and antiparkinsonian agents). An additional supplementary search included the references from the articles found. Studies were included if splitting content was directly related to psychoactive medications and examined the effect of tablet splitting on drug uniformity, weight uniformity, and adherence of psychoactive drugs. Articles were systematically reviewed and examined regarding the study design, methodology, and results of the study. A total of 125 articles were screened, and 13 were selected. Tablet splitting implications are extensive, yet substantial deviations from the ideal weight, potency, and dose uniformity are more ...Continue Reading

Citations

Feb 7, 2020·Therapeutic Delivery·Marcilio Cunha-FilhoTais Gratieri
Sep 22, 2020·Therapeutic Advances in Psychopharmacology·Peter C Groot, Jim van Os
Oct 19, 2019·Medicine·Kanika ChaudhriEmily R Atkins
Sep 3, 2021·Therapeutic Advances in Psychopharmacology·Peter C Groot, Jim van Os

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