Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation

The American Journal of Chinese Medicine
Yuan XuGuangchang Pang

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory and debilitating disease that involves the systemic imbalance of the immune network. Previous studies have shown that acupuncture can help treat RA. However, its specific mechanisms are not fully understood. Thus, the present study was designed to clarify the mechanisms of acupuncture acted on RA via immune network modulation using complete Freund's adjuvant (CFA)-induced arthritic rats. Results revealed that manual acupuncture (MA) could alleviate the inflammation and pain of infected joints. Moreover, MA could effectively stimulate the innate immune cytokines (IL-1[Formula: see text], IL-1[Formula: see text], IL-6, IL-7, IL-18, TNF-[Formula: see text]) and adaptive immunity cytokines (IL-2, IL-12, IFN-[Formula: see text], IL-4, IL-5, IL-10, IL-13, IL-17) as the main part of the immune response and repaired damage of RA. These complex immunomodulatory processes were analyzed quantitatively by cell-cell communication (CCC) networks. The CCC networks demonstrated that the immune networks were enhanced with the development of RA, while MA enhanced the immune networks in the early stage to act on RA and promoted the immune-network to a normal level at the lat...Continue Reading

References

Sep 26, 2006·Brain, Behavior, and Immunity·Robert Ader, Keith W Kelley
Jan 16, 2007·Annals of the Rheumatic Diseases·J M van WoerkomJ W J Bijlsma
Mar 8, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Kyoung YimJung-Eun Kim
Jul 28, 2007·Scandinavian Journal of Rheumatology·J R Kirwan
Aug 19, 2007·BMC Complementary and Alternative Medicine·Aihui LiLixing Lao
May 25, 2010·Autonomic Neuroscience : Basic & Clinical·Fusako KagitaniHarumi Hotta
Jun 1, 2010·Nature Neuroscience·Nanna GoldmanMaiken Nedergaard
Dec 16, 2010·Clinical and Experimental Immunology·D WangW Wei
Aug 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Yi LiangJun-Fan Fang
Nov 3, 2011·International Journal of Biological Macromolecules·Haiping LiGuangchang Pang
Dec 15, 2012·Lancet Neurology·Benoit D RousselStefan J Marciniak
Dec 11, 2013·Anesthesiology·Ruixin ZhangBrian M Berman
Feb 25, 2014·Nature Medicine·Rafael Torres-RosasLuis Ulloa
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon
Feb 21, 2016·Journal of Acupuncture and Meridian Studies·André T A Gonçalves de FreitasMaria D Bedoya Henao
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
Jan 17, 2017·Nature Neuroscience·Valentin A Pavlov, Kevin J Tracey
Nov 11, 2017·The American Journal of Chinese Medicine·See Yoon SeoYoon Jae Lee

❮ Previous
Next ❯

Citations

Feb 2, 2019·Chinese Journal of Integrative Medicine·Fu-Ming YangYang-Yang Liu
Mar 7, 2020·The American Journal of Chinese Medicine·Li QiaoYe Yang
Jul 23, 2019·The American Journal of Chinese Medicine·Hong-Ru ZhangSheng-Feng Lu
Feb 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jie ZhouJianqiao Fang
Jul 1, 2020·Medical Acupuncture·Wahyuningsih DjaaliIrma Nareswari
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yangyang LiuYi Guo
Dec 11, 2020·The American Journal of Chinese Medicine·Qi LiangLingxiang Liu
Mar 13, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Shou-Hai HongYi Guo
Mar 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fuming YangZhifang Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.