Acupuncture decreases neuropeptide Y expression in the hypothalamus of rats with Streptozotocin-induced diabetes

Acupuncture & Electro-therapeutics Research
Jae-Dong LeeChang-Ju Kim

Abstract

It has been known that acupuncture has various effects such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders. Neuropeptide Y (NPY), a 36-amino-acid peptide, is known to increase appetite. In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes. Needling on Zusanli resulted in decreased NPY levels in both the ARN and PVN of diabetic rats. The present study shows that acupuncture suppressed NPY expression in the ARN and PVN of the Hypothalamus in STZ-induced diabetic rats, suggesting the possibility that acupuncture treatment is effective in curbing the hyperphagia of diabetes.

Citations

Aug 1, 2007·Neuropeptides·Jun YangBao-Cheng Lin
Jul 2, 2010·Diabetes, Obesity & Metabolism·F Liang, D Koya
Feb 25, 2006·Pharmacology, Biochemistry, and Behavior·Sun Kwang KimByung-Il Min
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jade Heejae Ko, Seung-Nam Kim
Dec 14, 2011·Experimental Biology and Medicine·Ladan EshkevariSusan E Mulroney
Jul 21, 2020·World Journal of Gastroenterology : WJG·Zhi Yu

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