Abstract
Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke. Studies were obtained from six databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP information database, and Chinese Biomedical Literature Database, Ultimately, 34 studies containing 1617 animals were identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and GFAP were selected as major outcomes. The pooled results of 15 studies marked with Brdu showed significant effects of acupuncture for improving proliferation when compared with control groups (P < 0.01); 13 studies marked with Nestin showed significant effects of acupuncture for increasing proliferation when compared with control groups (P < 0.01); 4 studies marked with PSA-NCAM showed significant effects of acupuncture for enhancing migration when compared with control groups (P < 0.01); 4 studies marked with NeuN showed significant effects o...Continue Reading
References
Jan 18, 1978·Experimental Brain Research·A Cupello, H Hydén
Feb 23, 1990·Cell·U LendahlR D McKay
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 3, 2004·Stroke; a Journal of Cerebral Circulation·Malcolm R MacleodGeoffrey A Donnan
Dec 6, 2005·Experimental Brain Research·Sharmila JivanLev N Novikov
Apr 19, 2006·Acupuncture & Electro-therapeutics Research·Zeng-Jin YangFeng-Yan Sun
Oct 6, 2006·Brain Research Reviews·Philippe Taupin
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Apr 18, 2008·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Zhuoxin YangMin Pi
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Jul 29, 2008·Brain & Development·Sun Jin-qiaoYang Yi
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Shubo ZhongBo-Ying Chen
Dec 9, 2008·Neurological Research·Songming ChengXinfeng Liu
Apr 21, 2009·Lancet Neurology·Zheng Gang Zhang, Michael Chopp
May 13, 2009·Neurological Research·Jing TaoXiang-Bin Wang
Feb 20, 2010·Stroke; a Journal of Cerebral Circulation·Ping WuDugald Seely
Apr 28, 2010·PloS One·Daniele Fanelli
Aug 18, 2010·Experimental Neurology·Maria KreuzbergKonstantin Khodosevich
Nov 3, 2010·Journal of Neurochemistry·Sean P Murphy, Anne N Murphy
Oct 11, 2011·Journal of Acupuncture and Meridian Studies·Min-Ho NamSeung-hoon Choi
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Koji AbeNobutaka Kawahara
Oct 13, 2012·Nature·Story C LandisShai D Silberberg
Feb 2, 2013·Stroke; a Journal of Cerebral Circulation·Edward C JauchUNKNOWN Council on Clinical Cardiology
Feb 6, 2014·Scientific Reports·Wen-wen WangGuo-qing Zheng
Mar 4, 2014·PloS One·Yu Ri KimByung Tae Choi
Jun 14, 2014·Nature Communications·Zheng WuGong Chen
Jul 31, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew K TobinOrly Lazarov
Sep 2, 2014·Frontiers in Neuroanatomy·Pooja Balaram, Jon H Kaas
Citations
May 27, 2017·BMC Complementary and Alternative Medicine·Yu-Kang KimHi-Joon Park
Nov 7, 2016·Neurochemistry International·Yan CaoCun-Zhi Liu
Nov 17, 2017·International Journal of Molecular Sciences·Lina M ChavezYi-Hung Chen
Aug 26, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jacqueline Atsuko TidaLuiza da Silva Lopes
Feb 3, 2018·Scientific Reports·Yu Ri KimByung Tae Choi
Aug 30, 2017·Stem Cells International·Yuqin YeXiaosheng He
Apr 28, 2019·Medicine·Yan ZhangJian-Cheng Wang
Feb 13, 2020·Brain Sciences·Jae-Hong KimJeong-Soon Lee
Feb 7, 2020·The Clinical Journal of Pain·Dorine LenoirMira Meeus
Jul 18, 2017·International Journal of Molecular Medicine·Jingsong WuJing Tao
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sunjung ParkEun Jin Yang
Jun 29, 2016·Scientific Reports·Sung Min AhnByung Tae Choi
May 21, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Wen ZhuCun-Zhi Liu
Apr 7, 2018·Neural Regeneration Research·Reggie H C LeeHung Wen Lin
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jade Heejae Ko, Seung-Nam Kim
Jun 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hyongjun JeonSeungtae Kim
Nov 30, 2019·Stem Cell Research & Therapy·Fangxia GuanShanshan Ma
Sep 23, 2020·Medicine·Chang-Ho HanSeung-Yeon Cho
Jun 11, 2020·Journal of Molecular Neuroscience : MN·Shuqi YaoNenggui Xu
Apr 27, 2018·Scientific Reports·Meng HuangGuanghong Ding
Jan 14, 2021·Chinese Medicine·Xuke HanShifen Xu
Dec 22, 2020·Frontiers in Behavioral Neuroscience·Lu BaiLong Wang
Feb 7, 2021·Medicine·Junjun SunMiansheng Zhu
Apr 10, 2021·Medicine·Yihao ZhouGan Huang
Jun 5, 2021·Medicine·Yi-Mei ZhangGuo-Feng Zhou
Jun 8, 2021·Frontiers in Neurology·Shao-Ang ChuHao-Kuang Wang
Jul 1, 2021·Neural Plasticity·Qiuyi LvYihuai Zou
Jul 27, 2021·Frontiers in Aging Neuroscience·Cong-Mei WangHe-Fan He
Sep 8, 2021·Frontiers in Human Neuroscience·Jinhuan ZhangHaibo Yu
Nov 17, 2021·Neural Regeneration Research·Lu-Lu YaoNeng-Gui Xu
Dec 21, 2021·Neuroscience·Man LongNina Yin