Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis

Scientific Reports
Lin LuZhao-xiang Bian

Abstract

Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke. Studies were obtained from six databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP information database, and Chinese Biomedical Literature Database, Ultimately, 34 studies containing 1617 animals were identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and GFAP were selected as major outcomes. The pooled results of 15 studies marked with Brdu showed significant effects of acupuncture for improving proliferation when compared with control groups (P < 0.01); 13 studies marked with Nestin showed significant effects of acupuncture for increasing proliferation when compared with control groups (P < 0.01); 4 studies marked with PSA-NCAM showed significant effects of acupuncture for enhancing migration when compared with control groups (P < 0.01); 4 studies marked with NeuN showed significant effects o...Continue Reading

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Citations

Nov 17, 2017·International Journal of Molecular Sciences·Lina M ChavezYi-Hung Chen
Aug 26, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jacqueline Atsuko TidaLuiza da Silva Lopes
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sunjung ParkEun Jin Yang
May 21, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Wen ZhuCun-Zhi Liu
Apr 7, 2018·Neural Regeneration Research·Reggie H C LeeHung Wen Lin
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jade Heejae Ko, Seung-Nam Kim
Jun 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hyongjun JeonSeungtae Kim
Jun 11, 2020·Journal of Molecular Neuroscience : MN·Shuqi YaoNenggui Xu
Dec 22, 2020·Frontiers in Behavioral Neuroscience·Lu BaiLong Wang
Jul 27, 2021·Frontiers in Aging Neuroscience·Cong-Mei WangHe-Fan He

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