Acupuncture has a positive effect on asthmatic rats in a glucocorticoid-independent manner

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Wen-Qian WangYong-Qing Yang

Abstract

There is some evidence to support the use of acupuncture as an alternative therapy for asthma. However, the mechanisms underlying its effects are not fully understood. We have reported previously that acupuncture has beneficial effects on asthma without changing the concentration of serum cortisol, although endogenous glucocorticoid (GC) plays an important role in regulating immune responses. In this study, bilateral adrenalectomy (removal of both adrenal glands) was performed in rats before asthma model induction to investigate whether acupuncture influences asthma in a GC-dependent manner. Adrenal-intact and adrenalectomised rats were injected with ovalbumin to induce asthma and then left untreated or treated with manual acupuncture (MA) at GV14, bilateral BL12 and bilateral BL13, or manual restraint without MA. Healthy and sham-adrenalectomised control groups were also included. Pulmonary resistance (RL), serum concentrations of corticosterone, and eosinophil counts were measured at the end of the experimental course. Sera from adrenal-intact and adrenalectomised asthmatic rats treated with acupuncture were injected into untreated adrenal-intact and adrenalectomised asthmatic rats to investigate further the potential role of...Continue Reading

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Citations

Nov 9, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yaqun LiangAngela Wei Hong Yang
Jun 4, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Ida NurwatiMuthmainah Muthmainah
Jun 17, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jie CuiWenqian Wang
Apr 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jian XiongFanRong Liang

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