Abstract
There is some evidence to support the use of acupuncture as an alternative therapy for asthma. However, the mechanisms underlying its effects are not fully understood. We have reported previously that acupuncture has beneficial effects on asthma without changing the concentration of serum cortisol, although endogenous glucocorticoid (GC) plays an important role in regulating immune responses. In this study, bilateral adrenalectomy (removal of both adrenal glands) was performed in rats before asthma model induction to investigate whether acupuncture influences asthma in a GC-dependent manner. Adrenal-intact and adrenalectomised rats were injected with ovalbumin to induce asthma and then left untreated or treated with manual acupuncture (MA) at GV14, bilateral BL12 and bilateral BL13, or manual restraint without MA. Healthy and sham-adrenalectomised control groups were also included. Pulmonary resistance (RL), serum concentrations of corticosterone, and eosinophil counts were measured at the end of the experimental course. Sera from adrenal-intact and adrenalectomised asthmatic rats treated with acupuncture were injected into untreated adrenal-intact and adrenalectomised asthmatic rats to investigate further the potential role of...Continue Reading
References
Jul 1, 1991·American Journal of Respiratory Cell and Molecular Biology·J H FisherT Hofmann
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·G EnhorningR C Welliver
Nov 11, 1998·JAMA : the Journal of the American Medical Association
May 4, 2004·Journal of Applied Physiology·Thomas GlaabHeinz G Hoymann
Nov 29, 2005·Respiratory Research·Thomas GlaabHeinz G Hoymann
Feb 5, 2008·Journal of Managed Care Pharmacy : JMCP·Frank L Urbano
Oct 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lei-Miao YinYong-Qing Yang
May 8, 2009·Journal of Biomedical Science·Lei-Miao YinYong-Qing Yang
Jan 21, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Suqin ZhangXinmin Zhang
Mar 17, 2010·Cytokine·E R CarneiroV L F Silveira
Jun 12, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Leslie A Marino, Joannie Shen
Jun 18, 2010·Trends in Pharmacological Sciences·Peter J Barnes
Aug 13, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jun-Yong ChoiSung-Ki Jung
Mar 28, 2012·General and Comparative Endocrinology·Lee KorenKatherine Wynne-Edwards
May 9, 2012·Nature Medicine·Sally E Wenzel
Jun 5, 2012·Clinical Reviews in Allergy & Immunology·Yong-Qing YangJun Ran
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Dong XuYong-Qing Yang
Feb 20, 2014·Mucosal Immunology·M L ManniJ F Alcorn
Jun 11, 2014·The Journal of Cell Biology·David J Erle, Dean Sheppard
Sep 15, 2014·The Journal of Allergy and Clinical Immunology·Maureen GeorgeJudy A Shea
Nov 28, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ying WeiJingcheng Dong
Citations
Nov 9, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yaqun LiangAngela Wei Hong Yang
Jun 4, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Ida NurwatiMuthmainah Muthmainah
Jun 17, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jie CuiWenqian Wang
Apr 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jian XiongFanRong Liang