Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice

The Journal of Physiological Sciences : JPS
Seung-Tae KimJoo-Ho Chung

Abstract

We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)-induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 microg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions.

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Citations

Aug 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chang-Hwan BaeSeung-Tae Kim
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dongman ChaoYing Xia
Feb 20, 2015·BioMed Research International·Hsiu-Ling Tsai, Sue-Joan Chang
Jun 12, 2009·Current Neurology and Neuroscience Reports·Caitlin McElroy-Cox
Jul 10, 2012·The Journal of Physiological Sciences : JPS·Seung-Tae KimHi-Joon Park
Jul 8, 2020·International Journal of Molecular Sciences·Tzu-Hsuan Wei, Ching-Liang Hsieh

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