Acupuncture inhibits mammalian target of rapamycin, promotes autophagy and attenuates neurological deficits in a rat model of hemorrhagic stroke.

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Hao LiuXiao-Wei Sun

Abstract

Intracerebral hemorrhage (ICH) accounts for approximately 15% of all stroke cases. Previous studies suggested that acupuncture may improve ICH-induced neurological deficits. Therefore, we investigated the effects of acupuncture on neurological deficits in an animal model of ICH. Adult male Sprague-Dawley rats were injected with autologous blood (50 μL) into the right caudate nucleus. Additional rats underwent sham surgery as controls. ICH rats either received acupuncture (GV20 through GB7 on the side of the lesion) or sham acupuncture (1 cm to the right side of the traditional acupuncture point locations). Some ICH rats received acupuncture plus rapamycin injection into the right lateral ventricle. Neurological deficits in the various groups were assessed based on composite neurological score. The perihemorrhagic penumbra was analyzed by histopathology following hematoxylin-eosin staining. Levels of autophagy-related proteins light chain (LC)3 and p62 as well as of mammalian target of rapamycin (mTOR)-related proteins, and phosphorylated (p)-mTOR and p-S6K1 (ribosomal protein S6 kinase beta-1), were assessed by Western blotting. Acupuncture significantly improved composite neurological scores 7 days after ICH (17.7 ± 1.49 vs 14...Continue Reading

References

Dec 20, 2005·Lancet Neurology·Guohua XiJulian T Hoff
Nov 8, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yangdong HeGuohua Xi
Jul 8, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Sae Uchida, Harumi Hotta
Jan 22, 2010·American Journal of Physiology. Cell Physiology·Maryam MehrpourPatrice Codogno
Sep 3, 2010·Nature Cell Biology·Noboru Mizushima, Beth Levine
Jun 16, 2012·Lancet Neurology·Richard F KeepGuohua Xi
Oct 15, 2014·PLoS Biology·Andrew Thorburn
Feb 21, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hai-Dong GuoGuo-Hong Cui
Nov 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shi ShuChang-Quan Ling
Feb 9, 2017·Journal of Stroke·Jun Yup Kim, Hee-Joon Bae
Jun 18, 2017·Complementary Therapies in Medicine·Hao LiuHui Wang
Feb 23, 2018·Annals of Clinical and Translational Neurology·Meiling WuLing-Hui Zeng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms