PMID: 8959774Nov 1, 1996Paper

Acute administration of T3 or rT3 failed to improve outcome following resuscitation from cardiac arrest in dogs

Resuscitation
S E WhitesallL G D'Alecy

Abstract

Documentation of profound changes in serum thyroid hormone concentrations associated with cardiac arrest and resuscitation, as well as other acute emergencies, have spurred evaluation of possible therapeutic thyroid hormone administration. Acute and significant, this state, characterized by abnormally low serum thyroid hormone concentrations, may indicate selective thyroid replacement therapy. In a previous investigation, post-resuscitation infusion of levothyroxine sodium (L-T4) to normalize serum 3,5,3'-triiodothyronine (T3) concentrations was associated with significant reduction of neurologic deficit caused by severe global cerebral ischemia. Since L-T4 has been reported to act directly or via one of its metabolites, most likely T3, this most active form of thyroid hormone was tested. When L-T4 reduced the neurologic deficit, an increase in 3,3',5'-triiodothyronine (rT3) was also observed. This study therefore determined whether a post-resuscitation treatment with either T3 (n = 8) or rT3 (n = 8) provided protection against global cerebral ischemia comparable to that of L-T4. Global cerebral ischemia was achieved with 9 min of ventricular fibrillation. Following resuscitation, one of three solutions (saline group as a contr...Continue Reading

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Citations

Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·L G D'Alecy
Apr 27, 2002·Heart Disease·T KelschW H Frishman
Sep 30, 2010·Veterinary Clinical Pathology·Theresa PancottoKurt L Zimmerman
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Kenan IltumurNizamettin Toprak

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