Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans

Drug and Alcohol Dependence
Joshua A LileCraig R Rush

Abstract

Drugs affecting central gamma-aminobutyric acid (GABA) systems may have promise as treatments for cocaine addiction. In the present study, tiagabine (Gabatril), a GABA reuptake inhibitor, was investigated for its ability to modify the discriminative-stimulus, reinforcing, subject-rated, performance and cardiovascular effects of oral cocaine in non-treatment seeking cocaine users. Initially, acute doses of 4 mg tiagabine were tested alone and in combination with oral cocaine in four participants to establish the safety of cocaine-tiagabine combinations. A higher dose of tiagabine (8 mg) was then tested in a larger group (n = 6). Participants learned to discriminate 150 mg of oral cocaine. The effects of cocaine (0-150 mg, p.o.) administered alone and in combination with tiagabine were then determined. Subject-rated, performance and cardiovascular measures were obtained at regular intervals. The reinforcing effects of cocaine, tiagabine and cocaine-tiagabine combinations were assessed using the Multiple-Choice Procedure. Cocaine alone produced prototypical behavioral and physiological effects (i.e., functioned as a discriminative and reinforcing stimulus, produced stimulant-like subject-rated effects, improved performance and inc...Continue Reading

References

Jan 1, 1990·Psychopharmacology·S T HigginsJ W Fenwick
Sep 1, 1989·Canadian Journal of Physiology and Pharmacology·T Inaba
Jun 1, 1971·The American Journal of Psychiatry·M L Selzer
Jan 1, 1980·Psychopharmacology·M W Fischman, C R Schuster
Mar 1, 1995·Drug and Alcohol Dependence·R W FoltinF R Levin
Jan 1, 1993·Psychopharmacology·S T HigginsM A Capeless
Oct 1, 1995·Drug and Alcohol Dependence·E V NunesD F Klein
Jun 1, 1996·Psychopharmacology·M E Abreu, R R Griffiths
Aug 26, 1998·Drug and Alcohol Dependence·R A Wise
Apr 26, 2000·Behavioural Pharmacology·D H EpsteinK L Preston
Mar 10, 2001·The Journal of Clinical Psychiatry·H MyrickR Malcolm
Nov 23, 2001·Journal of Psychoactive Drugs·H MyrickM Measom
Nov 29, 2002·Psychopharmacology·Carl L HartMarian W Fischman
Apr 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Craig R RushLon S Hays
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Jamie L HagaCraig R Rush
Jul 3, 2004·Journal of Clinical Psychopharmacology·Craig R RushPaul E A Glaser

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Citations

Jun 29, 2005·Psychopharmacology·Mehmet SofuogluThomas Kosten
Feb 1, 2007·Psychopharmacology·Christoph FehrMathias Schreckenberger
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua A LileCraig R Rush
Jun 18, 2005·Behavioural Pharmacology·M B GatchM J Forster
May 19, 2007·Addiction Biology·Antonio Preti
Mar 1, 2006·Expert Opinion on Emerging Drugs·Mehmet Sofuoglu, Thomas R Kosten
May 16, 2009·Drug and Alcohol Dependence·Lawrence P Carter, Roland R Griffiths
Apr 26, 2008·Drug and Alcohol Dependence·S D ComerS L Walsh
Jun 17, 2006·European Journal of Pharmacology·Małgorzata FilipEdmund Przegaliński
Dec 8, 2005·Pharmacology, Biochemistry, and Behavior·Mehmet SofuogluThomas R Kosten
Oct 29, 2005·European Journal of Pharmacology·Christian Heidbreder
Sep 27, 2005·Pharmacology, Biochemistry, and Behavior·Joshua A LileCraig R Rush
Jul 12, 2005·Drug and Alcohol Dependence·Elise M WeertsRoland R Griffiths
Sep 15, 2005·Drug and Alcohol Dependence·Margaret HaneyRichard W Foltin
Aug 24, 2007·Journal of Psychopharmacology·Lori M LievingSylvain O Nouvion
Jul 23, 2020·Neurotoxicity Research·Regina Célia Cussa KubruslyAlex Christian Manhães

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