Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice

Frontiers in Pharmacology
Gabriella ContariniFrancesco Papaleo

Abstract

The maturation of attentional control during adolescence might influence later functional outcome or predisposition to psychiatric disorders. During adolescence, the cannabinoid system is particularly sensitive to pharmacological challenges, with potential impact on cognitive functions. Here, we used a recently validated five-choice serial reaction time task protocol to test adolescent C57BL/6J mice. We showed that the pharmacological inhibition (by URB597) of the fatty acid amide hydrolase (FAAH), the major enzyme implicated in anandamide degradation, prevented cognitive disruptions induced by distracting cues in adolescent mice. In particular, these protective effects were indicated by increased accuracy and correct responses and decreased premature responses selectively in the distractor trials. Notably, at the relatively low dose used, we detected no effects in other cognitive, motor, or incentive measures nor long-lasting or rebound effects of FAAH inhibition in cognitive functions. Overall, these data provide initial evidence of selective procognitive effects of FAAH inhibition in measures of attentional control in adolescent mice.

References

May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·L HanusR Mechoulam
Mar 7, 2002·JAMA : the Journal of the American Medical Association·Nadia SolowijUNKNOWN Marijuana Treatment Project Research Group
Dec 4, 2002·Nature Medicine·Satish KathuriaDaniele Piomelli
Nov 5, 2003·Nature Reviews. Neuroscience·Daniele Piomelli
Mar 3, 2004·Neurobiology of Learning and Memory·Marco CostanziClaudio Castellano
Dec 7, 2005·British Journal of Pharmacology·Angelo JayamanneChristopher W Vaughan
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tania AguadoIsmael Galve-Roperh
May 9, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
Jul 13, 2006·CNS Drug Reviews·Daniele PiomelliDavid Putman
Oct 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen A VarvelAron H Lichtman
Jan 16, 2007·Trends in Pharmacological Sciences·Tibor HarkanyKen Mackie
May 26, 2007·Science·Paul BerghuisTibor Harkany
Apr 22, 2008·European Journal of Pharmacology·Tommy PattijAnton N M Schoffelmeer
Jul 10, 2009·European Archives of Psychiatry and Clinical Neuroscience·Ismael Galve-RoperhManuel Guzmán
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iroise DumontheilSarah-Jayne Blakemore
Jun 21, 2011·Biological Psychiatry·Arnau Busquets-GarciaAndrés Ozaita
Sep 29, 2011·Frontiers in Behavioral Neuroscience·Claudio ZanettiniSevil Yasar
Nov 10, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gisli H GudjonssonSusan Young
Nov 23, 2011·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Staci A GruberScott E Lukas
Feb 23, 2013·Cell and Tissue Research·Miriam Schneider
Mar 21, 2013·Pharmacological Reviews·Jacqueline L Blankman, Benjamin F Cravatt
Jun 17, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonia ManducaViviana Trezza
Nov 21, 2014·Nature Reviews. Neuroscience·Mauro MaccarroneTibor Harkany
Mar 21, 2015·Journal of Attention Disorders·Ortal SlobodinItai Berger
Mar 31, 2015·Psychopharmacology·Alvaro Llorente-BerzalCarsten T Wotjak
Jul 29, 2015·Chemistry and Physics of Lipids·Laura ScalviniMarco Mor
Oct 1, 2015·Genes, Brain, and Behavior·T T-Y LeeF S Lee
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria MorenaPatrizia Campolongo
Nov 13, 2015·Psychopharmacology·Leigh V PanlilioZuzana Justinova
Mar 2, 2016·Translational Psychiatry·N D HartleyS Patel
Apr 8, 2016·Nature Reviews. Neuroscience·H Valerie CurranLoren H Parsons
May 19, 2016·International Journal of Clinical Pharmacology and Therapeutics·Christophe MalletChristian Dualé
May 20, 2016·BMJ : British Medical Journal·Nicholas Moore

❮ Previous
Next ❯

Citations

Apr 23, 2020·International Journal of Molecular Sciences·Adam StasiulewiczAnd Joanna I Sulkowska
May 20, 2020·Expert Opinion on Drug Discovery·Kevin Butler, Bernard Le Foll

❮ Previous
Next ❯

Software Mentioned

Statistica
MED
Windows
- PC

Related Concepts

Related Feeds

Cannabis & Cognition

The effect of cannabis on cognitive functioning is being explored for short and long-term effects. Recent studies have shown conflicting results, with some showing no significant effects and others showing neuropsychological impairment. Discover the latest research on cannabis and cognition here.