Acute Adverse Events After Spinal Cord Injury and Their Relationship to Long-term Neurologic and Functional Outcomes: Analysis From the North American Clinical Trials Network for Spinal Cord Injury

Critical Care Medicine
Fan JiangNorth American Clinical Trials Network Collaborators

Abstract

There are few contemporary, prospective multicenter series on the spectrum of acute adverse events and their relationship to long-term outcomes after traumatic spinal cord injury. The goal of this study is to assess the prevalence of adverse events after traumatic spinal cord injury and to evaluate the effects on long-term clinical outcome. Multicenter prospective registry. Consortium of 11 university-affiliated medical centers in the North American Clinical Trials Network. Eight-hundred one spinal cord injury patients enrolled by participating centers. Appropriate spinal cord injury treatment at individual centers. A total of 2,303 adverse events were recorded for 502 patients (63%). Penalized maximum logistic regression models were fitted to estimate the likelihood of neurologic recovery (ASIA Impairment Scale improvement ≥ 1 grade point) and functional outcomes in subjects who developed adverse events at 6 months postinjury. After accounting for potential confounders, the group that developed adverse events showed less neurologic recovery (odds ratio, 0.55; 95% CI, 0.32-0.96) and was more likely to require assisted breathing (odds ratio, 6.55; 95% CI, 1.17-36.67); dependent ambulation (odds ratio, 7.38; 95% CI, 4.35-13.06) a...Continue Reading

References

Mar 1, 1994·Archives of Physical Medicine and Rehabilitation·A B Jackson, T E Groomes
Nov 24, 1999·Archives of Physical Medicine and Rehabilitation·W O McKinleyM J DeVivo
May 24, 2001·Annals of Surgery·M A CroceT C Fabian
Nov 15, 2002·Neurosurgery·M N HadleyT C Ryken
Oct 22, 2003·Spinal Cord·S Aito, UNKNOWN Gruppo Italiano Studio Epidemiologico Mielolesioni GISEM Group
Jan 30, 2004·The Journal of Trauma·Jeffrey G ChipmanGreg J Beilman
Nov 3, 2004·Archives of Physical Medicine and Rehabilitation·William McKinleyBarbara Barnard
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·Yuying ChenAmie B Jackson
Aug 23, 2005·Accident; Analysis and Prevention·Peter J O'Connor
Jan 6, 2006·The Journal of Trauma·Bryan A CottonC William Schwab
May 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Timothy P McHenryJens R Chapman
Dec 21, 2007·The Journal of Spinal Cord Medicine·Dustin D FrenchDeborah Gavin-Dreschnack
Mar 21, 2008·Journal of Neurotrauma·Maxwell BoakyeShivanand P Lad
Feb 25, 2009·Archives of Physical Medicine and Rehabilitation·Mary Ann ReganUNKNOWN Spinal Cord Injury Rehabilitation Evidence Research Team
Nov 4, 2009·The Journal of Bone and Joint Surgery. American Volume·A PloumisA R Vaccaro
Dec 25, 2009·Journal of Neurotrauma·Steven Casha, Sean Christie
Apr 21, 2010·The Journal of Trauma·John R DimarLeah Y Carreon
Apr 7, 2012·Archives of Physical Medicine and Rehabilitation·Stephen MacciocchiKimether Barlow
Sep 19, 2012·Journal of Neurosurgery. Spine·Bizhan AarabiMichael K Rosner
Sep 19, 2012·Journal of Neurosurgery. Spine·Robert G GrossmanJames S Harrop
Oct 27, 2012·Brain : a Journal of Neurology·Vieri FailliJan M Schwab
Mar 30, 2013·Neurosurgery·Timothy C RykenBeverly C Walters
Feb 22, 2013·The Journal of Trauma and Acute Care Surgery·Étienne Bourassa-MoreauStefan Parent
Aug 29, 2013·The Spine Journal : Official Journal of the North American Spine Society·John T StreetMarcel F Dvorak
Oct 22, 2013·Journal of Neurotrauma·Shalini SelvarajahEric B Schneider
May 20, 2015·Practical Neurology·Alexander E RopperNicholas Theodore
May 23, 2015·Neuroepidemiology·Jonviea D ChamberlainMartin W G Brinkhof
Dec 3, 2016·Seminars in Neurology·Gary Schwartzbauer, Deborah Stein
Dec 7, 2016·Spinal Cord·L Y Garcia-ArguelloN Safdar
Nov 2, 2017·Neurosurgical Focus·John K YueSanjay S Dhall
Nov 21, 2017·The Spine Journal : Official Journal of the North American Spine Society·Rebecca MitchellJacqueline Close

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Citations

Jun 11, 2020·Journal of Orthopaedic Surgery and Research·Zhi-Meng WangDing-Jun Hao

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