Acute aerobic exercise induces a preferential mobilisation of plasmacytoid dendritic cells into the peripheral blood in man

Physiology & Behavior
Frankie F BrownJ E Turner

Abstract

Dendritic cells (DCs) are important sentinel cells of the immune system responsible for presenting antigen to T cells. Exercise is known to cause an acute and transient increase in the frequency of DCs in the bloodstream in humans, yet there are contradictory findings in the literature regarding the phenotypic composition of DCs mobilised during exercise, which may have implications for immune regulation and health. Accordingly, we sought to investigate the composition of DC sub-populations mobilised in response to acute aerobic exercise. Nine healthy males (age, 21.9 ± 3.6 years; height, 177.8 ± 5.4 cm; body mass, 78.9 ± 10.8 kg; body mass index, 24.9 ± 3.3 kg·m2; V̇O2 MAX, 41.5 ± 5.1 mL·kg·min-1) cycled for 20 min at 80% V̇O2 MAX. Blood was sampled at baseline, during the final minute of exercise and 30 min later. Using flow cytometry, total DCs were defined as Lineage- (CD3, CD19, CD20, CD14, CD56) HLA-DR+ and subsequently identified as plasmacytoid DCs (CD303+) and myeloid DCs (CD303-). Myeloid DCs were analysed for expression of CD1c and CD141 to yield four sub-populations; CD1c-CD141+; CD1c+CD141+; CD1c+CD141- and CD1c-CD141-. Expression of CD205 was also analysed on all DC sub-populations to identify DCs capable of recog...Continue Reading

Citations

Jul 25, 2018·Journal of Functional Morphology and Kinesiology·Francesca LuchettiAlexandrina Ferreira Mendes
Oct 29, 2020·NPJ Microgravity·Alexander Choukér, Alexander C Stahn
Jul 4, 2021·Journal for Immunotherapy of Cancer·Michael P GustafsonRichard J Simpson
Sep 7, 2021·Leukemia & Lymphoma·Nathaniel R WilsonNaveen Pemmaraju

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