Acute alcohol impairs conditioning of a behavioural reward-seeking response and inhibitory control processes--implications for addictive disorders.

Addiction
Sabine Loeber, Theodora Duka

Abstract

To investigate whether acute alcohol would affect performance of a conditioned behavioural response to obtain a reward outcome and impair performance in a task measuring inhibitory control to provide new knowledge of how the acute effects of alcohol might contribute to the transition from alcohol use to dependence. A randomized controlled between-subjects design was employed. The laboratory of experimental psychology at the University of Sussex. Thirty-two light to moderate social drinkers recruited from the undergraduate and postgraduate population. After the administration of alcohol (0.8 g/kg) or placebo participants underwent an instrumental reward-seeking procedure, with abstract stimuli serving as S+ (always predicting a win of 10 pence) and S- (always predicting a loss of 10 pence). In addition, a Stop Signal task was administered before and after the administration of alcohol. Participants of the alcohol group performed the behavioural response to obtain the reward outcome more often than placebo subjects in trials associated with loss of money. This finding was observed, although alcohol was not affecting explicit knowledge of stimulus-response outcome contingencies and acquisition of conditioned attentional and emotio...Continue Reading

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Citations

Apr 13, 2013·Psychopharmacology·Amy Jane CaswellTheodora Duka
Jul 17, 2013·Progress in Neurobiology·Andrea Bari, Trevor W Robbins
Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Leon Kenemans, Seppo Kähkönen
Jan 31, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyriaki NikolaouTheodora Duka
Nov 19, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·E López-CanedaS Doallo
Dec 15, 2015·Psychiatry Research. Neuroimaging·Enrico CollantoniAngela Favaro
Jan 17, 2016·Biological Psychiatry·Laura E KwakoDavid Goldman
Jan 5, 2011·Neuropharmacology·Brian A McCool
Mar 13, 2009·Drug and Alcohol Dependence·Sabine Loeber, Theodora Duka
Jul 30, 2015·Psychopharmacology·Marcia SpoelderLouk J M J Vanderschuren
Jun 12, 2013·Drug and Alcohol Dependence·Ayca Coskunpinar, Melissa A Cyders
Aug 21, 2013·Consciousness and Cognition·Rebecca Semmens-WheelerTheodora Duka
Aug 15, 2014·Psychological Medicine·T B MoleV Voon
Aug 27, 2016·Alcoholism, Clinical and Experimental Research·Sandra Sanchez-RoigeTheodora Duka
Feb 19, 2015·Journal of Psychopharmacology·Catherine CashRaimondo Bruno
Dec 21, 2010·Journal of Psychopharmacology·Theodora DukaDavid N Stephens
Oct 31, 2019·Psychopharmacology·Juliette Tobias-WebbLuke Clark
Jun 22, 2019·Addiction Biology·Silvana De PirroAldo Badiani
Feb 9, 2017·Journal of Psychopharmacology·Eduardo López-CanedaFernando Cadaveira
May 21, 2020·Psychological Research·Yang LiuWery P M van den Wildenberg

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