Abstract
We examined the effects of acute alcohol on basal plasma FSH, LH, and prolactin in ovariectomized rats. Alcohol infusion and blood sampling were done via an indwelling atrial catheter. Blood samples for alcohol and hormone determinations were collected before, and 5 to 120 min after completion of saline (control) or alcohol in saline (experimental) infusion. Plasma follicle-stimulating hormone, luteinizing hormone, and prolactin were not altered during the 2-hr period. Peak blood alcohol concentrations achieved following 1.0- and 2.0-g/kg body weight of alcohol doses were approximately equal to, and twice, the legal human intoxication levels, respectively. Alcohol clearance rates from blood for the two groups were: 130 +/- 3 mg/kg/hr for the 1.0-g/kg body weight group and 151 +/- 3 mg/kg/hr for the 2.0-g/kg body weight group. These results show that acute alcohol does not affect basal gonadotropins and prolactin secretion in ovariectomized rats.
References
Nov 1, 1979·Clinics in Endocrinology and Metabolism·D H Van Thiel, R Lester
Dec 1, 1978·The Journal of Endocrinology·C A Blake
Mar 1, 1978·The Journal of Clinical Investigation·D H Van ThielR Lester
Mar 1, 1989·Alcohol·N K MelloA Skupny
Feb 7, 1986·Science·C RivierW Vale
Jan 1, 1987·Advances in Experimental Medicine and Biology·R T Savoy-Moore, K H Swartz
Mar 1, 1988·Alcohol·M G Subramanian, E L Abel
Jul 1, 1987·Alcohol·H BegleiterM Eckardt
Jan 1, 1987·Alcohol·P Sirota, F J Boland
Jan 1, 1985·General Pharmacology·M AlfonsoJ Marcó
Sep 1, 1985·Alcohol·W L DeesS M McCann
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·J H MendelsonS Bavli
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·R SanchisC Guerri
Sep 1, 1970·Acta Endocrinologica·J D Kieffer, M M Ketchel
May 1, 1984·Alcohol·W L DeesG P Kozlowski
Jan 1, 1984·Journal of Substance Abuse Treatment·M R HawkinsD R Sittig
Sep 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·M A NiarakiK S Moghissi
Aug 12, 1983·Science·N K MelloP Sehgal
Jun 1, 1980·Clinical Endocrinology·J N HuguesE Modigliani
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·R L EskayE Majchrowicz
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·T J Cicero
Jun 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·E M CRANSTON
Citations
Mar 1, 1995·Alcohol·M G Subramanian
Apr 14, 1997·Drug and Alcohol Dependence·P P Vescovi, V Coiro
Aug 1, 1997·Alcoholism, Clinical and Experimental Research·M G Subramanian
Oct 1, 1992·Alcoholism, Clinical and Experimental Research·C RivierW Vale
Apr 1, 1992·Alcoholism, Clinical and Experimental Research·J A Mitchell, B R Van Kainen
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·J A Mitchell
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·M G SubramanianB A Bergeski