PMID: 2502977Jul 1, 1989Paper

Acute alcohol intoxication paired with aversive reinforcement: ethanol odor as a conditioned reinforcer in rat pups

Behavioral and Neural Biology
J C Molina, M G Chotro

Abstract

Previous research has suggested that infant rats process ethanol sensory properties during acute alcohol intoxication. The present study was designed in order to examine if alcohol odor could act as an aversive conditioned stimulus after the organism experiences the state of intoxication paired with nociceptive stimulation (footshock). In a first experiment 11-day-old pups received intragastric alcohol administration (1.5 g/kg). At different postabsorptive intervals footshock was presented (0-30, 30-60, 60-90, or 90-120 min). An explicitly unpaired control group which experienced footshock prior to the state of intoxication was also employed. All animals were subsequently tested in terms of alcohol intake and ethanol locational odor preferences. Both assessments indicated that pups which were exposed to the unconditioned peripheral stimulus 30-60 min after receiving ethanol expressed strong alcohol aversions. In a second experiment pups were exposed to footshock during this postabsorptive interval. Twenty four hours later, pups experienced ambient ethanol odor paired with soft or rough texture surfaces. Differential texture aversions were registered in experimental animals when compared with controls which suffered the state of...Continue Reading

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Citations

Jan 5, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·P S Hunt, R A Hallmark
Jul 14, 2011·Psychopharmacology·Roberto Sebastián Miranda-MoralesPaula Abate
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·H D DominguezJ C Molina
Nov 1, 1990·Behavioral and Neural Biology·P S HuntN E Spear
Mar 10, 2001·Physiology & Behavior·R D Mattes, D DiMeglio
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·M Y PepinoJ C Molina
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Ricardo M PautassiJuan Carlos Molina
Mar 24, 2012·Alcohol·Michael E NizhnikovNorman E Spear
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Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Juan Carlos MolinaNorman E Spear
Jan 7, 2006·Alcohol·Ricardo Marcos PautassiJuan Carlos Molina
Oct 4, 2007·Behavioural Pharmacology·M Gabriela Chotro, Carlos Arias
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Roberto Sebastián Miranda-MoralesJuan Carlos Molina
Sep 1, 1991·Brain Research Bulletin·E TabuchiM Kawasaki

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