Acute amino acid loads that deplete brain serotonin fail to alter behavior

Pharmacology, Biochemistry, and Behavior
C M BrownD V Coscina

Abstract

Acute depletion of brain serotonin (5-HT) can be induced in both rats and humans by giving an amino acid load deficient in tryptophan (TRY). Because this treatment is relatively easy to administer and short-acting, it seems well suited for studying mood and/or behavioral changes linked to aberrant 5-HT functioning in humans. To investigate the ability of a TRY-deficient amino acid load to induce behavioral changes in animals, this study measured performance on an operant schedule of differential reinforcement of low rates of responding (DRL), locomotor activity in both novel and familiar environments, and paw-lick latencies on a hot-plate. All of these measures have been found previously to be altered by impairments of the brain 5-HT system. Adult male Sprague-Dawley rats were administered by gavage an amino acid load lacking TRY, an amino acid load containing TRY, or distilled water. Three hours later, behavioral tests were conducted. Although 5-HT levels were decreased in the hippocampus (-23.3%) and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in the striatum (-35.1%) and hippocampus (-38.5%), there were no effects of the TRY-deficient load on any of the behavioral tests. Because reliable mood-altering effects h...Continue Reading

References

Sep 1, 1975·Journal of Comparative and Physiological Psychology·J AntinG P Smith
Aug 11, 1975·Journal of Comparative and Physiological Psychology·W C AitkenP Ellen
Jan 1, 1986·Annals of the New York Academy of Sciences·C M BankiC D Kilts
Dec 1, 1984·Neuropharmacology·M H Roberts
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
Sep 1, 1994·Journal of Affective Disorders·D B MenkesJ P Fawcett
Dec 1, 1994·Biological Psychiatry·A W GoddardL H Price
Apr 1, 1993·Biological Psychiatry·C J McDougleL H Price
Jan 1, 1994·Journal of Psychopharmacology·A D OldmanP J Cowen

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Citations

Aug 5, 2003·BMC Psychiatry·Peter GallagherR Hamish McAllister-Williams
Sep 13, 2002·Psychopharmacology·A Richard Green, Iain S McGregor
Jul 20, 2005·Biological Psychiatry·Nicole Praschak-RiederJeffrey H Meyer
Oct 7, 2004·European Journal of Pharmacology·Vera BubeníkováCyril Höschl
Sep 6, 2008·Progress in Brain Research·Marcy J Bubar, Kathryn A Cunningham
Jun 20, 2008·Journal of Psychopharmacology·T C ArdisS J Cooper
Feb 23, 2011·Molecular Psychiatry·E L van DonkelaarJ Prickaerts
Dec 4, 2003·Molecular Psychiatry·L BooijW J Riedel

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