Abstract
Acute depletion of brain serotonin (5-HT) can be induced in both rats and humans by giving an amino acid load deficient in tryptophan (TRY). Because this treatment is relatively easy to administer and short-acting, it seems well suited for studying mood and/or behavioral changes linked to aberrant 5-HT functioning in humans. To investigate the ability of a TRY-deficient amino acid load to induce behavioral changes in animals, this study measured performance on an operant schedule of differential reinforcement of low rates of responding (DRL), locomotor activity in both novel and familiar environments, and paw-lick latencies on a hot-plate. All of these measures have been found previously to be altered by impairments of the brain 5-HT system. Adult male Sprague-Dawley rats were administered by gavage an amino acid load lacking TRY, an amino acid load containing TRY, or distilled water. Three hours later, behavioral tests were conducted. Although 5-HT levels were decreased in the hippocampus (-23.3%) and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in the striatum (-35.1%) and hippocampus (-38.5%), there were no effects of the TRY-deficient load on any of the behavioral tests. Because reliable mood-altering effects h...Continue Reading
References
Jun 15, 1979·Brain Research·J L GibbonsS F Leibowitz
Sep 1, 1975·Journal of Comparative and Physiological Psychology·J AntinG P Smith
Aug 11, 1975·Journal of Comparative and Physiological Psychology·W C AitkenP Ellen
Jan 1, 1992·Psychopharmacology·M A WogarE Szabadi
Jan 1, 1991·Journal of Neurochemistry·R InvernizziR Samanin
May 1, 1990·Psychiatry Research·A ApterS L Brown
May 1, 1985·Alcohol·S BorgP Valverius
Jan 1, 1986·Annals of the New York Academy of Sciences·C M BankiC D Kilts
Jan 1, 1989·Life Sciences·E A MojaO Tofanetti
Jul 1, 1988·Psychiatry Research·R S KahnT Strauman
May 1, 1974·Journal of Neurochemistry·G L GessaA Tagliamonte
Jan 1, 1974·Psychopharmacologia·D J SangerD E Blackman
Oct 27, 1972·Science·J D Fernstrom, R J Wurtman
Jul 9, 1971·Science·J D Fernstrom, R J Wurtman
Dec 1, 1984·Neuropharmacology·M H Roberts
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
Dec 26, 1983·Life Sciences·M LinnoilaF K Goodwin
Jun 1, 1995·Psychopharmacology·R O PihlF R Ervin
Sep 1, 1994·Journal of Affective Disorders·D B MenkesJ P Fawcett
Dec 1, 1994·Biological Psychiatry·A W GoddardL H Price
Apr 1, 1993·Biological Psychiatry·C J McDougleL H Price
Sep 1, 1995·Psychological Medicine·A OldmanP J Cowen
Jun 1, 1994·Behavioural Pharmacology·P.J. Fletcher
Jan 1, 1994·Journal of Psychopharmacology·A D OldmanP J Cowen
Citations
Apr 16, 2004·Behavioural Brain Research·Cindy K J LiebenArjan Blokland
Sep 10, 2003·Neurochemistry International·C K J LiebenN E P Deutz
Aug 5, 2003·BMC Psychiatry·Peter GallagherR Hamish McAllister-Williams
Sep 13, 2002·Psychopharmacology·A Richard Green, Iain S McGregor
Nov 15, 2011·Journal of Psychiatric Research·M FranklinS Gaburro
Sep 1, 2009·Neurochemistry International·Eva L van DonkelaarJos Prickaerts
Jul 8, 2009·Neuroscience·E L van DonkelaarP A T Kelly
May 29, 2007·Neuroscience·L A W JansA Blokland
Jun 19, 2013·Acta Psychiatrica Scandinavica·E L van DonkelaarA Blokland
Jul 20, 2005·Biological Psychiatry·Nicole Praschak-RiederJeffrey H Meyer
Oct 7, 2004·European Journal of Pharmacology·Vera BubeníkováCyril Höschl
Sep 6, 2008·Progress in Brain Research·Marcy J Bubar, Kathryn A Cunningham
Dec 17, 2008·Journal of Psychopharmacology·L A W JansA Blokland
Jun 20, 2008·Journal of Psychopharmacology·T C ArdisS J Cooper
Jun 3, 2008·Journal of Psychopharmacology·A SambethJ A J Schmitt
Apr 13, 2002·Journal of Psychopharmacology·Arjan BloklandNicolaas E P Deutz
Feb 23, 2011·Molecular Psychiatry·E L van DonkelaarJ Prickaerts
Dec 4, 2003·Molecular Psychiatry·L BooijW J Riedel
Mar 11, 2017·Psychopharmacology·A MerchánP Flores
Apr 13, 2019·Translational Psychiatry·Sofi da Cunha-BangGitte M Knudsen
Feb 13, 2021·Physiology & Behavior·A MerchánP Flores