PMID: 16634328Apr 26, 2006Paper

Acute amitriptyline intoxication: an analysis of 44 children

Human & Experimental Toxicology
Hüseyin CaksenCahide Yilmaz

Abstract

The tricyclic antidepressant agents, particularly amitriptyline and dothiepin, are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. In this article, the clinical and laboratory findings of 44 children with amitriptyline intoxication are reviewed. Our purpose was to investigate amitriptyline intoxication in childhood. Of 44 patients, 21 (47.7%) were boys, 23 (52.3%) were girls, and the ages ranged from 12 months to 14 years (mean +/- SD; 4.09 +/- 2.9 years). All children except one who took an overdose of amitriptyline to decrease his pain accidentally ingested an overdose of amitriptyline. The amount of amitriptyline ingested was between 2 mg/kg and 97.5 mg/kg (mean +/- SD; 13.6 +/- 17.7 mg/kg per dose) (the drug dosage was not known in 13 children). The most commonly observed clinical and laboratory findings were lethargy, tachycardia, convulsion, hyperglycemia and leukocytosis. In all patients except for two children who died the abnormal clinical and laboratory findings returned to normal within a few days after admission and they were discharged from the hospital in good health within the fourth day of admission. One of the children ingested 97.5 mg/kg amitriptyline and p...Continue Reading

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Citations

Apr 3, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alan ClementJennifer A Lowry
Jun 3, 2009·Child and Adolescent Psychiatric Clinics of North America·John Fanton, Mary Margaret Gleason
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Feb 14, 2015·Forensic Science International : Synergy·Nathalie AllibeFrançoise Stanke-Labesque
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Sep 26, 2012·Pediatrics·Nathalie S M LakPaul H G Hogeman

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