PMID: 9443662Jan 27, 1998Paper

Acute amphetamine and/or phencyclidine effects on the dopamine receptor specific binding in the rat brain

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
M TomićJ Joksimović

Abstract

Psychotic-like behaviour was induced in rats with a single i.p. injection of AMPH (20 mg/kg b.w.) and/or PCP (10 mg/kg b.w.). The D1 and D2 dopamine receptor (DAR) specific binding of [3H]SCH 23390 and [3H]spiperone, respectively, during the 120 min period upon the treatment was examined on cryosections using computerized scanning and image analysis. AMPH, alone or in combination with PCP, induced a transient decrease of the D1 receptor specific binding in the striatum (30 min; AMPH, -18%; AMPH+PCP, -31%) and nucleus accumbens (30 min; AMPH, -30%; AMPH+PCP, -40%), which was completely abolished at the 120 min point. Only AMPH persistently elevated nigral D1 receptor specific binding. PCP-induced striatal and accumbal D1 receptor down-regulation was intensive throughout the 120 min period, while in the s. nigra it was non-significant. A significant increase of the D2 receptor specific binding was observed only 30 min after the treatment in striatum (AMPH, 15%; PCP, 16%; AMPH+PCP, 13%) and n. accumbens (AMPH, 16%). These alterations of DAR specific binding may reflect a regulation of the DAR and the changes in nigrostriatal and mesolimbic DA-ergic neurotransmission during an intensive drug-induced psychotic-like behavioral expres...Continue Reading

References

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Citations

Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Ratna Sircar, Karam F A Soliman
Feb 17, 2000·Neurochemistry International·M Tomić, J Joksimović
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erkki Tupala, Jari Tiihonen
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Victoria S Dalton, Katerina Zavitsanou
Jun 24, 2008·The International Journal of Neuropsychopharmacology·Abesh K BhattacharjeeStanley I Rapoport

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