PMID: 2508945Oct 14, 1989Paper

Acute and chronic arterial and venous effects of captopril in congestive cardiac failure

BMJ : British Medical Journal
S CapewellA L Muir

Abstract

To determine whether captopril alters peripheral venous tone in patients with congestive cardiac failure. Open study of patients at start of captopril treatment and three months later. A hospital gamma camera laboratory. 16 Men with congestive cardiac failure in New York Heart Association class II or III, aged 57-73. Patients were initially given 500 micrograms sublingual glyceryl trinitrate followed by 25 mg oral captopril. The study was then repeated after three months' captopril treatment. Previously validated non-invasive radionuclide techniques were used to measure changes in central haemodynamic variables and peripheral venous volumes in the calf. After 25 mg captopril there were falls in blood pressure and relative systemic vascular resistance and increases in cardiac index and left ventricular ejection fraction. This was accompanied by a 16% increase in peripheral venous volume (95% confidence interval 13.4% to 18.4%, p less than 0.01), which compared with an 11% increase after 500 micrograms glyceryl trinitrate (10% to 12%, p less than 0.01). Eleven patients were restudied after three months' continuous treatment with captopril. The resting venous volume was higher than it had been initially, by about 10%, and increase...Continue Reading

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Citations

Sep 28, 2005·Cardiovascular Drugs and Therapy·Iain M MacIntryeJohn J V McMurray
Feb 1, 1995·Pharmacology & Therapeutics·J R CockcroftD J Webb
Feb 1, 1991·British Journal of Clinical Pharmacology·S Capewell, A Capewell
Oct 1, 1994·British Journal of Clinical Pharmacology·W H Aellig
Nov 18, 1989·BMJ : British Medical Journal·D J Webb, J R Cockcroft
Jun 1, 1992·British Heart Journal·A D Hargreaves, A L Muir
Jun 1, 1991·American Heart Journal·A L Muir, J Nolan
Nov 18, 1989·BMJ : British Medical Journal

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