PMID: 8973384Sep 1, 1996Paper

Acute and chronic effects of amiodarone on mammalian ventricular cells

Japanese Heart Journal
I KodamaJ Toyama

Abstract

This article reviews experimental studies on the electrophysiological effects of amiodarone on mammalian hearts. Acute application of amiodarone (0.1-10 microM) to papillary muscles or single ventricular cells isolated from rabbits or guinea pigs caused a significant decrease in action potential duration (APD) as well as a marked use-dependent inhibition of the maximum upstroke velocity (Vmax) of action potential with fast recovery kinetics. Acute amiodarone also caused a concentration-dependent decrease in the calcium current (ICa) and the delayed-rectifier potassium current (IK). Action potentials recorded from papillary muscles or single ventricular cells isolated from the rabbits treated with oral amiodarone (100 mg/kg daily, 4 weeks) were characterized by a moderate frequency-independent prolongation of APD. There was no use-dependent Vmax inhibition. The ventricular cells treated with chronic amiodarone showed a significant decrease in the current density of ICa, IK and Ito. The amount of mRNA for Kv1.5, a Shaker-related potassium channel from the rats treated with chronic oral amiodarone was significantly lower than that from control rats. These results suggest that the major and consistent effects of chronic amiodarone ...Continue Reading

Citations

Nov 24, 1999·The American Journal of Cardiology·I KodamaJ Toyama
Aug 2, 2003·Journal of Cardiovascular Electrophysiology·Nathalie LalevéeSylvain Richard
Feb 17, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Datun QiGan-Xin Yan
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·F ChenG T Wetzel
Apr 18, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Erika Hrudikova VyskocilovaIvana Kacirova
Jul 22, 2020·Canadian Journal of Physiology and Pharmacology·Tamás Árpádffy-LovasLászló Virág
Apr 28, 2018·Journal of the American College of Cardiology·Sofia ChatzidouStylianos Rokas

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