Acute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives

Physiology & Behavior
Alan J MetcalfePhilipp Zimmer

Abstract

Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

Citations

Mar 4, 2020·Nutrients·Christopher WeyhBarbara Strasser
Apr 20, 2020·European Journal of Applied Physiology·Niklas JoistenPhilipp Zimmer
Apr 14, 2019·Molecular Psychiatry·Jonathan Savitz
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Terry PurtonWolfgang Marx
Feb 9, 2021·Journal of Strength and Conditioning Research·Lisa UmlauffMoritz Schumann
Sep 4, 2021·European Journal of Applied Physiology·A PalP Zimmer

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