PMID: 2497482Jan 1, 1989Paper

Acute and chronic effects of psychotropic drugs on maternal aggression in mice

Psychopharmacology
H Yoshimura, N Ogawa

Abstract

The present study investigated the acute and chronic effects of psychotropic drugs on maternal aggression in mice. All female mice had been singly housed since the end of the 4-day mating period. Behavioral testing for acute drug effects was carried out on postpartum days 5 and 7. Chronic drug treatment was started immediately after removal of the partner male, and was terminated on the 3rd postpartum day; behavioral testing was done on the 5th postpartum day. Acute administration of chlordiazepoxide (CDP; 5, 10 and 15 mg/kg, IP) showed a biphasic effect on maternal aggression; 10 mg/kg CDP significantly increased the frequency of bites, while 15 mg/kg CDP significantly decreased it. Imipramine (IMP; 5, 10 and 15 mg/kg, IP) decreased the frequency of bites in a dose-dependent manner. Haloperidol (HAL; 0.1, 0.2 and 0.4 mg/kg, IP) also decreased the frequency of bites dose dependently, but 0.2 and 0.4 mg/kg HAL decreased both the frequency and duration of locomotion. Chronic treatment with either CDP (5 and 10 mg/kg, IP) or HAL (0.1 and 0.2 mg/kg, IP) failed to alter the frequency of bites. This evidence indicates that the antidepressant imipramine has a specific action in alleviating postpartum female aggression, and suggests th...Continue Reading

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Citations

Jul 23, 1991·European Journal of Pharmacology·H Yoshimura, N Ogawa
May 1, 1996·Pharmacology, Biochemistry, and Behavior·P PalanzaS Parmigiani
Mar 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J MosB Olivier
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Joseph S Lonstein, Stephen C Gammie
Dec 17, 2009·Behavioral Neuroscience·Grace Lee, Stephen C Gammie
Apr 1, 2003·CNS Drugs·Torbjörn BäckströmDi Zhu
Feb 6, 2007·Pharmacology, Biochemistry, and Behavior·Grace Lee, Stephen C Gammie
Jan 18, 2006·European Journal of Pharmacology·Mellisa N CarrHiroyuki Yoshimura
Mar 11, 2009·Psychoneuroendocrinology·Lotta AndréenTorbjörn Bäckström
Sep 18, 2012·Behavioural Brain Research·Elimelech NesherAlbert Pinhasov
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Aug 15, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sedigheh HantoushzadehFatemeh Golshahi

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