PMID: 40287Aug 8, 1979

Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice

L de Angelis, Sandra E File


The effects on active social interaction of acute and chronic dosage with diazepam (1 mg/kg), desmethyldiazepam (2 mg/kg), and chlor-desmethyl-diazepam (0.125 mg/kg) were studied in pairs of mice. The mice were tested under either high or low levels of illumination. In all cases acute drug treatment significantly reduced social interaction, but this was not seen with chronic treatment (9 days). Two of the drugs, diazepam and desmethyldiazepam, showed an anxiolytic action, i.e., these drugs resulted in significantly less variation in social interaction with the change in light levels, compared with vehicle-injected controls.


Jan 1, 1978·British Journal of Pharmacology·Sandra E File, J R Hyde
Sep 1, 1973·The Journal of Pathology·M E Chitiyo


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Jul 27, 1979·Brain Research·Sandra E File
Jul 16, 1982·European Journal of Pharmacology·H C Rosenberg, T H Chiu
Sep 1, 1988·European Journal of Pharmacology·L A Hilakivi, R G Lister
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·Sandra E File, R J Rodgers
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Jun 1, 1994·Pharmacology, Biochemistry, and Behavior·P F Smith, C L Darlington
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J N Crawley
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Jan 1, 1990·Pharmacology & Therapeutics·R G Lister
Dec 1, 1979·Journal of Affective Disorders·Sandra E File, J R Hyde
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·L A LumleyJ L Meyerhoff
Mar 1, 1997·Pharmacology, Biochemistry, and Behavior·R K McNamara, R W Skelton
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