PMID: 40287Aug 8, 1979

Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice

Psychopharmacology
L de Angelis, Sandra E File

Abstract

The effects on active social interaction of acute and chronic dosage with diazepam (1 mg/kg), desmethyldiazepam (2 mg/kg), and chlor-desmethyl-diazepam (0.125 mg/kg) were studied in pairs of mice. The mice were tested under either high or low levels of illumination. In all cases acute drug treatment significantly reduced social interaction, but this was not seen with chronic treatment (9 days). Two of the drugs, diazepam and desmethyldiazepam, showed an anxiolytic action, i.e., these drugs resulted in significantly less variation in social interaction with the change in light levels, compared with vehicle-injected controls.

References

Jan 1, 1978·British Journal of Pharmacology·Sandra E File, J R Hyde
Sep 1, 1973·The Journal of Pathology·M E Chitiyo

Citations

Jun 16, 2004·Psychopharmacology·Andras Bilkei-GorzoAndreas Zimmer
Dec 25, 2004·Psychopharmacology·Bettina BertAntonia G Nasello
Nov 26, 2009·Behavior Genetics·Aki TakahashiTsuyoshi Koide
Jul 27, 1979·Brain Research·Sandra E File
Jul 16, 1982·European Journal of Pharmacology·H C Rosenberg, T H Chiu
Sep 1, 1988·European Journal of Pharmacology·L A Hilakivi, R G Lister
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·Sandra E File, R J Rodgers
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J N Crawley, F K Goodwin
Jun 1, 1994·Pharmacology, Biochemistry, and Behavior·P F Smith, C L Darlington
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J N Crawley
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·H C Rosenberg, T H Chiu
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D Treit
Jan 1, 1990·Pharmacology & Therapeutics·R G Lister
Dec 1, 1979·Journal of Affective Disorders·Sandra E File, J R Hyde
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·L A LumleyJ L Meyerhoff
Mar 1, 1997·Pharmacology, Biochemistry, and Behavior·R K McNamara, R W Skelton
Aug 31, 2013·Nature Reviews. Drug Discovery·Guy Griebel, Andrew Holmes
Nov 3, 2012·Journal of Allergy·Jonathan S Tam, Mitchell H Grayson
Mar 15, 2000·Reviews in the Neurosciences·S M WeissC T Dourish
Feb 10, 2016·Molecular Brain·Ikuo MatsudaAtsu Aiba
Jan 30, 2016·Molecular Brain·Hirotaka ShojiTsuyoshi Miyakawa
Dec 20, 2011·Behavioural Brain Research·Andrew H FairlessEdward S Brodkin
Apr 22, 2009·Behavioural Brain Research·Michel Pratte, Marc Jamon
Sep 10, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrew H FairlessEdward S Brodkin
Jul 20, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takayuki DohkeToshihiko Yamashita
Dec 3, 2015·Current Protocols in Mouse Biology·Sabine M HölterWolfgang Wurst

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