Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Marilena VitaleAngela Albarosa Rivellese

Abstract

Postprandial metabolic abnormalities are considered important and independent risk factors for cardiovascular diseases. However, the effects of the Mediterranean diet on postprandial metabolism and the mechanism underpinning the effects on clinical variables have not been exhaustively explored. Therefore, the aims of the present study were to evaluate the acute and medium-term effects (8 weeks) on postprandial glucose and lipid metabolism of a diet resembling a typical Mediterranean diet (Med-D) compared to a western-type diet (Control-D), and the mechanisms underlying those effects. Twenty-nine overweight/obese individuals of both genders, aged 20-60 years, were enrolled and randomly assigned to two isoenergetic dietary interventions: 1) a Med-D (n = 16), and 2) a Control-D (n = 13). Adherence to the dietary interventions was assessed by a 7-day food record. A meal test resembling the assigned diet was performed at baseline and after 8 weeks of intervention. Blood samples at fasting and over 4-h after the meal were collected to assess metabolic parameters and short chain fatty acid (SCFA) levels. Fecal samples were also collected to evaluate the microbiota composition. Glucose and insulin responses were significantly reduced a...Continue Reading

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Citations

Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingyun LuXijie Yu
Aug 8, 2021·Gut Pathogens·A L CunninghamD A Harris
Aug 21, 2021·Frontiers in Cardiovascular Medicine·Xinyi ShenZhongqun Wang

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