Acute and chronic increases in excitability in rat hippocampal slices after perinatal hypoxia In vivo

Journal of Neurophysiology
Frances E JensenM C Stevens

Abstract

We have previously shown that hypoxia induces both acute and chronic epileptogenic effects that are age dependent. Global hypoxia (3-4% O2) induces seizure activity in the developing brain [postnatal day (P)10-12] but not at younger or older ages. Adult rats with prior seizures induced by hypoxia at P10 show increased seizure susceptibility to chemical convulsants compared with controls. In the present study, we tested the hypothesis that acute and chronic epileptogenic effects of hypoxia are demonstrable in hippocampus both in vivo and in vitro. Depth electrode recordings confirmed the presence of ictal activity within hippocampus in P10 rats during global hypoxia. Hippocampal slices prepared from P10 pups killed at 10 min after recovery from hypoxia showed evidence of increased excitability. Extracellular field recordings revealed that the amplitude and duration of long-term potentiation (LTP) was increased significantly in area CA1 of hippocampal slices removed from hypoxic pups. In addition, extracellular recordings within areas CA1 and CA3 showed significantly longer afterdischarge durations in response to kindling stimuli in slices from hypoxic pups compared with controls. To evaluate whether there were also long-term cha...Continue Reading

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Citations

Sep 25, 2001·Pediatric Research·E C WirrellJ Y Yager
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Frances E Jensen
Jun 26, 2004·The European Journal of Neuroscience·Hana KubováAsla Pitkänen
Aug 15, 2006·The European Journal of Neuroscience·Katherine G AkersAkaysha C Tang
Sep 1, 2007·Clinical Obstetrics and Gynecology·Alistair Jan Gunn, Peter D Gluckman
Dec 22, 2007·Toxicologic Pathology·Alok K SharmaPaul W Snyder
Feb 24, 2016·Brain Sciences·Gatambwa MukandalaJohn J O'Connor
Nov 3, 2016·Pediatric Research·Alistair J GunnLaura Bennet
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·F E Jensen, T Z Baram
Jul 12, 2012·Clinical and Experimental Pharmacology & Physiology·Laura BennetAlistair J Gunn
Sep 11, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Natalia Pozdnyakova
Mar 3, 2020·Frontiers in Pharmacology·Bridgette D SempleTerence J O'Brien
Apr 12, 2000·Journal of Neurophysiology·P CongarV Crépel
Jan 8, 2014·Annals of Neurology·Evelyn McClendonStephen A Back
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hongyu SunFrances E Jensen
Dec 17, 2017·Journal of Child Neurology·Sookyong Koh
Oct 17, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jacqueline SalasThierry A G M Huisman
Mar 20, 2008·Neuro-Signals·Guo ShaoGuo-Wei Lu
Apr 6, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew N ClarksonD Steven Kerr
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·A J Gunn, M Thoresen
Apr 17, 2018·The Journal of Physiology·Guido WassinkAlistair J Gunn
Apr 19, 2015·Journal of Biomedical Science·Silvia J López-PérezLaura Medina-Ceja
Feb 15, 2014·Clinics in Perinatology·Paul P DruryAlistair J Gunn
Sep 18, 2001·Annals of Neurology·S Koh, F E Jensen
Aug 8, 2021·International Journal of Molecular Sciences·Tatyana Y PostnikovaAleksey V Zaitsev

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