Acute and chronic morphine alters formalin pain in neonatal rats

Neuroscience Letters
Maurice H ZissenSarah M Sweitzer

Abstract

The present study tested the hypothesis that morphine exposure during the human developmental equivalent of the third trimester would alter inflammatory pain. This study examined whether acute or continuous opioid exposure in the neonatal rat alters formalin-induced nociception after 4 days of abstinence. Rats were exposed to a single acute administration of morphine on postnatal day 7 or 72 h of opioid infusion from postnatal days 5-7 via osmotic pump. When challenged with intraplantar formalin on postnatal day 11, rats exposed to acute or chronic morphine had increased phase II pain-associated behaviors. These findings suggest that neonatal morphine exposure may have unintended consequences on inflammatory pain.

References

Oct 1, 1992·Pain·Esther R Guy, Frances V Abbott
Aug 7, 1995·The Journal of Comparative Neurology·M L Reynolds, M Fitzgerald
Feb 12, 1998·Biology of the Neonate·K J Anand
Jul 1, 1999·Physiology & Behavior·K J AnandP M Plotsky
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Fitzgerald, E Jennings
Sep 28, 1999·Regional Anesthesia and Pain Medicine·W Rahman, A H Dickenson
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·S R ThorntonF L Smith
Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M Fitzgerald, S Beggs
Jun 24, 2003·Journal of Rehabilitation Medicine·Jens Schouenborg
Jul 4, 2003·Nature·Per PeterssonJens Schouenborg
Nov 13, 2003·JAMA : the Journal of the American Medical Association·Richard F Howard
Feb 27, 2004·Journal of Neurophysiology·Per PeterssonJens Schouenborg
Aug 17, 2004·Neuroscience Letters·Jennifer A ShumillaJoan J Kendig
Oct 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Wendy F SternbergLaura Scorr
Dec 8, 2004·Current Opinion in Neurobiology·Jens Schouenborg
Jul 5, 2005·British Journal of Anaesthesia·R D SandersM Maze
Oct 4, 2005·Brain & Development·Gyorgy Csaba, Kornélia Tekes

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Citations

Apr 22, 2014·Life Sciences·Anna FodorDóra Zelena
Nov 11, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mohammad H RohaniGila Behzadi
Oct 24, 2007·Peptides·Richard J Bodnar
Feb 13, 2008·Brain Research·Guo Hua Zhang, Sarah M Sweitzer
Oct 28, 2010·Brain Research·Joanna Ripoll RoziskyIraci Lucena da Silva Torres
Jan 4, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ellen A NunesIraci L S Torres

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