PMID: 11902816Mar 21, 2002Paper

Acute and chronic neutropenias. What is new?

Journal of Internal Medicine
J PalmbladG D Eliopoulos

Abstract

Recently, some of the mechanisms and consequences in the severe chronic neutropenias (e.g. the neutrophil elastase gene mutations and the risk to progress to myelodysplasia and acute leukaemia) and in drug-induced agranulocytosis (e.g. the apoptosis-inducing ability of metabolites of clozapine) have been elucidated, and new aspects of autoimmune and the large granular lymphocyte syndrome were described (e.g. aberrant elaboration of Fas-ligand causing neutrophil apoptosis). Investigations of the mild to moderate chronic neutropenias have shown the significance of interactions between the myeloid development and the immune network (e.g. relations to immunoglobulin aberrations). Granulocyte-colony stimulation factor (G-CSF) is widely used in patients with severe chronic neutropenia, however, its use in other conditions is mostly based on anecdotal evidence. In addition, immune modulating regimens, such as metothrexate, ciclosporine and monoclonal antibodies, are increasingly employed for the autoimmune neutropenias.

References

Mar 1, 1975·Acta paediatrica Scandinavica·R Kostman
Sep 1, 1992·British Journal of Haematology·J BuxC Mueller-Eckhardt
Jan 1, 1982·Acta Medica Scandinavica·P Arneborn, J Palmblad
Apr 17, 1980·The New England Journal of Medicine·R A Kyle
Apr 1, 1995·British Journal of Haematology·N J BishopA Prentice
Jan 1, 1995·The American Journal of Medicine·T CederholmK Hellström
Oct 1, 1994·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·P D ClearyG Oster
Oct 1, 1993·Transfusion Medicine Reviews·D F Stroncek
Aug 1, 1996·British Journal of Haematology·O P SmithP Milla
May 1, 1997·British Journal of Haematology·S B KillickE C Gordon-Smith
Mar 27, 1998·Current Opinion in Hematology·D C Dale
Feb 25, 1999·Archives of Internal Medicine·M M van der KlauwB H Stricker
Feb 26, 1999·Thyroid : Official Journal of the American Thyroid Association·S FukataM Sugawara
May 8, 1999·British Journal of Haematology·H W AunerH Sill
Dec 22, 1999·Archives of Internal Medicine·J Palmblad
Mar 15, 2000·Molecular and Cellular Endocrinology·I P TouwM H Hermans
Mar 31, 2000·Blood Reviews·T Lamy, T P Loughran
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B SchnyderW J Pichler
Jun 22, 2000·Molecular Pharmacology·D P WilliamsB K Park
Jul 11, 2000·British Journal of Haematology·C ZeidlerK Welte
Feb 13, 2001·The Journal of Clinical Investigation·P K Epling-BurnetteT P Loughran
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W S Armstrong, P Kazanjian
Apr 17, 2001·Current Opinion in Hematology·M A Smith, J G Smith
Aug 8, 2001·Clinical and Laboratory Haematology·H A PapadakiG D Eliopoulos
Sep 13, 2001·European Journal of Haematology·H A PapadakiG D Eliopoulos

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Citations

Jan 22, 2005·European Journal of Clinical Pharmacology·David EspositoFrédéric Limosin
Jul 27, 2007·Annals of Hematology·Vasiliki Vlacha, Gavriella Feketea
Feb 27, 2004·The American Journal of Medicine·Emmanuel AndrèsFrédéric Maloisel
Oct 10, 2002·Acta Anaesthesiologica Scandinavica·M TsuchiyaM Inoue
May 25, 2002·Journal of Internal Medicine·E AndrèsF Maloisel
Nov 13, 2004·Journal of Clinical Psychopharmacology·Igor MosyaginIngolf Cascorbi
May 11, 2004·Drugs & Aging·Emmanuel AndrèsFrédéric Maloisel
Dec 5, 2006·European Journal of Internal Medicine·Emmanuel AndrèsFrédéric Maloisel
Dec 26, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniel GarwiczBengt Fadeel
Mar 10, 2005·British Journal of Haematology·H A PapadakiG D Eliopoulos
May 26, 2007·Journal of Interventional Cardiology·Flavio RibichiniCorrado Vassanelli
Aug 16, 2014·Journal of Pharmacy Practice·Amy M Pick, Kelly K Nystrom
Sep 1, 2007·Journal of Pediatric Hematology/oncology·Deniz Yilmaz, Arthur Kim Ritchey
Jan 9, 2008·Pharmacoepidemiology and Drug Safety·L IbáñezUNKNOWN Agranulocytosis and Aplastic Anaemia Study Group of Barcelona
Nov 25, 2004·Hematology·Nancy BerlinerThomas P Loughran
Dec 1, 2008·Expert Review of Hematology·Helen A Papadaki, Charalampos Pontikoglou
Jun 14, 2020·Journal of Clinical Medicine·Noel Lorenzo-VillalbaEmmanuel Andrès

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