Acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus: a retrospective case-control study.

Radiation Oncology
Ajaykumar B PatelRobert C Miller

Abstract

The purpose of this study was to evaluate acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus (DLE). A retrospective review was performed of patients with DLE who received radiotherapy at our institution between 1980 and 2005. Patients with other connective tissue disorders were excluded. Control patients were matched 2:1 with the DLE treatment courses based on age, cancer diagnosis, year of treatment, radiotherapy dose, and sex. Acute (within 30 days from the completion of radiotherapy) and late toxicities were evaluated for each treatment course using the Common Terminology Criteria for Adverse Events Version 3.0. Twelve patients with DLE received a total of 15 radiotherapy courses. The median follow-up time was 2.6 years (range, 0.0-15.2 years). Acute toxicity of any organ was observed in 10 (67%) treatment courses, of which 2 (13%) were Grade 3 or higher. Acute Grade 1 or 2 dermatologic toxicity was observed in 8 courses (53%). Late toxicity of any organ was observed in 7 of 12 (58%) evaluable treatment courses, of which 3 (23%) were grade 3 or higher. Late grade 1 or 2 dermatologic toxicity was observed in 5 (42%) courses. No patient experienced acute or late Grade 3 or higher dermatolog...Continue Reading

References

Oct 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R FleckF A Holmes
May 1, 1988·Clinical and Experimental Dermatology·D J Eedy, J R Corbett
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M Morris, S N Powell
Jul 27, 1999·International Journal of Radiation Oncology, Biology, Physics·B De NaeyerJ Huys
May 3, 2005·The Journal of Dermatology·Akemi Ishida-YamamotoHajime Iizuka
Feb 1, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tobias HölscherMichael Baumann
Feb 21, 2006·Clinical and Experimental Dermatology·A MitraM D Goodfield
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Douglas G GoldThomas G Osborn
Dec 26, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Douglas G GoldPaul D Brown
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Melva E PinnRobert C Miller
May 29, 2008·Cancer·Alexander LinEdgar Ben-Josef
Mar 7, 2009·Journal of the American Board of Family Medicine : JABFM·Suresh Panjwani
Mar 19, 2009·Journal of the American Academy of Dermatology·Angelina ErcegMarieke M B Seyger
May 14, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N BookenM Goebeler

❮ Previous
Next ❯

Citations

Sep 29, 2015·Case Reports in Oncological Medicine·Stephanie A TerezakisJoachim Yahalom
Mar 15, 2016·The Lancet Oncology·Niccolò Giaj-LevraFilippo Alongi
Jul 22, 2018·The American Journal of Dermatopathology·Amin A HedayatGregory D Seidel
Aug 22, 2021·International Journal of Radiation Oncology, Biology, Physics·Parvez M ShaikhMatthew M Harkenrider

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.