Acute and long-term effects of clinical doses of antenatal glucocorticoids in the developing fetal sheep kidney.

Journal of the Society for Gynecologic Investigation
G Angela MassmannJorge P Figueroa

Abstract

The controversy regarding potential long-term side effects of antenatal steroid administration for accelerating fetal lung maturation is still unresolved despite more than 30 years of experience. Studies in animals have demonstrated that administration of glucocorticoids during pregnancy alters renal expression of several key regulatory molecules at different developmental stages followed in most cases with the development of hypertension in the adult. We studied the effects of betamethasone on the expression of (1) NA,K-ATPAse pump; (2) the Na/H exchanger 3 (NAHE3); (3) angiotensin receptor (AT1 and AT2); and (4) the type 1 dopamine receptor (D1R). Pregnant sheep were treated with either 0.17 mg/kg betamethasone or vehicle 24 hours apart at 80 and 81 days' gestation. Fetal kidneys were harvested at 81 and 135 days' gestation. Protein and mRNA levels were measured in kidney cortex. Betamethasone had acute and long-term effects on fetal kidney cortex gene expression. Acutely, mRNA abundance for AT2 was significantly lower and that of NHE3 significantly higher than in controls (0.4 +/- 0.02 vs 0.7 +/- 0.05; 1.2 +/- 0.16 vs 0.4 +/- 0.04; P < .05). At 135 days' gestation, AT2 receptor abundance remained lower than control (0.2 +/- ...Continue Reading

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Citations

Jul 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiaoyan WangPedro A Jose
Nov 28, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lijun TangJames C Rose
Jan 15, 2010·American Journal of Physiology. Renal Physiology·Stephen A ContagJames C Rose
Dec 23, 2011·American Journal of Physiology. Renal Physiology·Chih-Jen ChengMichel Baum
Jun 29, 2010·Pediatric Research·Delrae M EckmanJorge P Figueroa
May 29, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·R GuilhermeD Mitanchez
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Apr 18, 2014·Reproductive Sciences·Khurrum SiddiqueMichel Baum
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Anand RotteFlorian Lang
Mar 31, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G Angela MassmannJorge P Figueroa
May 9, 2014·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Ajit SelvendraDavid Castle
Sep 12, 2014·American Journal of Physiology. Renal Physiology·Jianli BiJames C Rose

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