PMID: 2117143Jan 1, 1990Paper

Acute and long-term effects of viral bronchiolitis in infancy

Lung
J F Price

Abstract

About 1% of infants are admitted to hospital with acute bronchiolitis; 85% of cases are caused by infection with Respiratory Syncytial Virus (RSV). The pathophysiological changes during the acute illness are inflammatory obstruction in the small airways with submucosal cellular infiltration, epithelial necrosis and mucous plugging; FRC increases and dynamic compliance falls. Failure to respond to bronchodilator drugs suggests that muscle spasm contributes relatively little to the airway narrowing. Affected infants become increasingly dyspnoeic and hypoxic for 3-4 days then spontaneously improve. After an attack of acute bronchiolitis up to 75% of children have recurrent lower respiratory tract symptoms, many continue to have hyperinflated lungs and bronchial hyperresponsiveness. In the majority, symptoms of cough and wheezing have subsided by the time they start school, but abnormalities of small airway function are detectable at least 13 years later. Children with a genetic predisposition to atopy do not appear to have an increased risk of developing bronchiolitis. Evidence of genetic predisposition to bronchial hyperresponsiveness in those with persistent wheezing is controversial. There is little to suggest that neonatal lun...Continue Reading

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Citations

Jun 12, 1998·Tropical Medicine & International Health : TM & IH·M W WeberB M Greenwood
Mar 29, 2002·Archives of Disease in Childhood·A Abul-Ainine, D Luyt
Sep 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·J Y KhanR K Firmin
Feb 12, 2010·Annals of the New York Academy of Sciences·Loralyn A Benoit, Michael J Holtzman
Jan 12, 2000·The Journal of Allergy and Clinical Immunology·E von Mutius
Nov 26, 2014·Infection and Immunity·Norberto González-JuarbeMolly A Bergman
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Jan 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·A B Gill, A M Weindling
Jul 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas W LukacsDennis M Lindell
May 29, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomoya IkedaTakaki Ishikawa
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian D RuddNicholas W Lukacs
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K K TekkanatN W Lukacs
Jun 23, 2021·Pediatric Pulmonology·Elie J MitriCarlos A Camargo

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