Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Ercüment AksakalDeniz Ekinci

Abstract

We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 microg/L, 1 microg/L and 2.5 microg/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day). The mRNA levels significantly decreased with increasing deltamethrin concentrations for acute administration. Interestingly, a significant recovery in GH-I expression was seen after the 72nd hour up to 30th day while no significant differences were observed for IGF-I and IGF-II between the same time intervals. Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I, IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.

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Citations

May 7, 2011·Biological Trace Element Research·Saltuk Buğrahan CeyhunŞükrü Beydemir
Sep 24, 2013·Environmental Toxicology and Pharmacology·Levent MercanDeniz Ekinci
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Dec 21, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Deniz EkinciOrhan Erdoğan
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Sep 17, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Murat ŞentürkÖmer İrfan Küfrevioglu
Nov 5, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Levent MercanDeniz Ekinci
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Feb 11, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Levent MercanClaudiu T Supuran
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Dec 8, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Ramazan DemirdağClaudiu T Supuran
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May 14, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Serdar BurmaoğluClaudiu T Supuran
May 16, 2012·Toxicology and Industrial Health·Sevcan Mercan, Banu Eren

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