Care of burn-injured patients requires knowledge of the pathophysiologic changes affecting virtually all organs from the onset of injury until wounds are healed. Massive airway and/or lung edema can occur rapidly and unpredictably after burn and/or inhalation injury. Hemodynamics in the early phase of severe burn injury is characterized by a reduction in cardiac output and increased systemic and pulmonary vascular resistance. Approximately 2 to 5 days after major burn injury, a hyperdynamic and hypermetabolic state develops. Electrical burns result in morbidity much higher than expected based on burn size alone. Formulae for fluid resuscitation should serve only as guideline; fluids should be titrated to physiologic endpoints. Burn injury is associated basal and procedural pain requiring higher than normal opioid and sedative doses. Operating room concerns for the burn-injured patient include airway abnormalities, impaired lung function, vascular access, deceptively large and rapid blood loss, hypothermia, and altered pharmacology.
Extrapulmonary factors influencing the ratio of arterial oxygen tension to inspired oxygen concentration in burn patients
Acute respiratory failure that complicates the resuscitation of pediatric patients with scald injuries
Tumescent local anesthesia for the surgical treatment of burns and postburn sequelae in pediatric patients
The efficacy of continuous fascia iliaca compartment block for pain management in burn patients undergoing skin grafting procedures
Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
Case records of the Massachusetts General Hospital. Case 5-2008. An 18-month-old girl with an advanced neck contracture after a burn
Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients
Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or large bolus
The severe burns patient with tracheostomy: implications for management of dysphagia, dysphonia and laryngotracheal pathology
Use of dexmedetomidine for sedation in critically ill mechanically ventilated pediatric burn patients
Phenylephrine tumescence in split-thickness skin graft donor sites in surgery for burn injury- a concentration finding study
Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study
Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival
Use of continuous local anesthetic infusion in the management of postoperative split-thickness skin graft donor site pain
Use of methylnaltrexone to induce laxation in acutely injured patients with burns and necrotizing soft-tissue infections
Immobilization with atrophy induces de novo expression of neuronal nicotinic α7 acetylcholine receptors in muscle contributing to neurotransmission
Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: a systematic review
Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury
Transpulmonary Thermodilution Versus Transthoracic Echocardiography for Cardiac Output Measurements in Severely Burned Children
Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target
Acute kidney injury after burn surgery: Preoperative neutrophil/lymphocyte ratio as a predictive factor
C1 Esterase Inhibitor Activity Is Reduced in the Acute Phase Following Burn Injury: A Prospective Observational Study
Should early amputation impact initial fluid therapy algorithms in burns resuscitation? A retrospective analysis using 3D modelling
Liposomal bupivacaine for the management of postsurgical donor site pain in patients with burn injuries: a case series from two institutions
Comparing the Effect of Gabapentin, Ketamine, Dexmedetomidine, and Entonox on Pain Control in Burn Wound Dressing
The expert evaluation of the cases of death from burn disease during the delayed post-traumatic period
Efficacy assessment of mesenchymal stem cell transplantation for burn wounds in animals: a systematic review
Immersive Virtual Reality as an Adjunctive Non-opioid Analgesic for Pre-dominantly Latin American Children With Large Severe Burn Wounds During Burn Wound Cleaning in the Intensive Care Unit: A Pilot Study
Relationship Between Patient Characteristics and Number of Procedures as well as Length of Stay for Patients Surviving Severe Burn Injuries: Analysis of the American Burn Association National Burn Repository.
Hyaluronic acid hydrogel loaded by adipose stem cells enhances wound healing by modulating IL-1β, TGF-β1, and bFGF in burn wound model in rat
Meeting the Challenge of Analgesia in a Pregnant Woman With Burn Injury Using Subanesthetic Ketamine: A Case Report and Literature Review
Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses.
The Descriptive Epidemiology and Outcomes of Hospitalized Burn Patients in Southern Turkey: Age-specific Mortality Patterns
Economic burden of moderate to severe burns and its association with health-related quality of life of Nigerian women.
Suxamethonium-Induced Hyperkalemia: A Short Review of Causes and Recommendations for Clinical Applications.
A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing
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Evolution of Pluripotency
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