Acute and persistent protein synthesis inhibition following cerebral reperfusion

Journal of Neuroscience Research
D J DeGracia

Abstract

Lack of recovery from protein synthesis inhibition (PSI) closely correlates with neuronal death following brain ischemia and reperfusion. It has therefore been suggested that understanding the mechanisms of PSI will shed light on the mechanisms of selective neuronal death following ischemia and reperfusion. It is now known that the PKR-like ER kinase (PERK)-mediated phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) causes translation inhibition at initial reperfusion. Activation of PERK, in turn, indicates endoplasmic reticulum stress and activation of the unfolded protein response. However, phosphorylation of eIF2alpha is a transient event and can account for PSI only in the initial hours of reperfusion. Although a number of other regulators of protein synthesis, such as eIF4F, 4EBP-1, eEF-2, and S6 kinase, have been assessed following cerebral ischemia and reperfusion, the causes of prolonged PSI have yet to be fully elucidated. The purpose of the present article is to bring together the evidence indicating that, at minimum, postischemic PSI should be conceptualized as consisting of two components: an acute, transient component mediated by unfolded protein response-induced eIF2alpha phosphorylation and a long...Continue Reading

References

Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W BodschK A Hossmann
Dec 24, 1971·Brain Research·P Kleihues, K A Hossmann
Nov 1, 1980·Journal of Neurochemistry·G A DienelT E Duffy
Sep 1, 1995·Journal of Neurochemistry·R W NeumarG S Krause
Jan 1, 1993·Progress in Brain Research·K A Hossmann
Dec 16, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J DeGraciaG S Krause
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R W NeumarG S Krause
Jun 29, 2000·Annual Review of Biochemistry·A C GingrasN Sonenberg
Oct 13, 2000·European Journal of Biochemistry·O Meyuhas
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Feb 13, 2001·Neurobiology of Disease·S JanelidzeB K Siesjö
Jul 11, 2001·Genes & Development·C U Hellen, P Sarnow
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Donald J DeGraciaBlaine C White
Mar 21, 2002·FEBS Letters·Alexey G Ryazanov
Nov 9, 2002·European Journal of Biochemistry·Gert C Scheper, Christopher G Proud
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takaaki Kirino
Feb 13, 2003·Current Opinion in Structural Biology·Nahum Sonenberg, Thomas E Dever
Apr 8, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rita KumarDonald J DeGracia

❮ Previous
Next ❯

Citations

Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Peter S VoslerJun Chen
Jun 19, 2009·The Journal of Biological Chemistry·María Dolores PastorSoledad Calvo
Aug 25, 2007·Antioxidants & Redox Signaling·George G RobertsDonald J DeGracia
May 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Zara MehrabianDhananjaya V Kalvakolanu
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong-wa YungGraham J Burton
Aug 25, 2010·Molecular and Cellular Biology·Xianrong R Mao, C Michael Crowder
Sep 14, 2007·Annual Review of Physiology·M Celeste SimonRegina M Young
Dec 11, 2013·Translational Stroke Research·Monique K LewisDonald J DeGracia
Dec 13, 2006·The European Journal of Neuroscience·Mehrdad ShamlooKaroly Nikolich
Jul 17, 2008·Journal of Neurochemistry·Donald J DeGraciaMonique K Lewis
Mar 21, 2006·Trends in Molecular Medicine·Gert C ScheperMarjo S van der Knaap
Jun 7, 2005·Biochimica Et Biophysica Acta·Heather L MontieDonald J Degracia
Apr 28, 2016·Brain Research·Vicente ValenzuelaFelipe A Court
Jul 7, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Haihui WangDonald J DeGracia
Aug 24, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Donald J DeGracia, Bingren R Hu
Nov 12, 2017·Translational Stroke Research·Donald J DeGracia
Jan 18, 2017·Wiley Interdisciplinary Reviews. RNA·Donald J DeGracia
Mar 15, 2016·World Journal of Gastroenterology : WJG·Joep GrootjansJoep P M Derikx

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.