PMID: 3748458Aug 4, 1986Paper

Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain

Neuroscience Letters
M L de CeballosC D Marsden

Abstract

Following acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but decreases in hypothalamus and frontal cortex. No change was observed in the striatum or substantia nigra. Repeated sulpiride administration caused a decrease in Leu-enkephalin content of the hypothalamus and cortex but not elsewhere.

References

May 1, 1977·Neuropharmacology·P N ElliottR Miller
Apr 1, 1977·Neuropharmacology·H Y YangE Costa
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F TangJ P Schwartz
Jan 1, 1984·Annual Review of Neuroscience·H AkilJ M Walker

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Citations

Jun 28, 1992·Annals of the New York Academy of Sciences·L StinusM Le Moal

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