Acute and repeated dose toxicity studies of different β-cyclodextrin-based nanosponge formulations

Journal of Pharmaceutical Sciences
Pravin ShendeFabrizio Caldera

Abstract

Nanosponges (NS) show promising results in different fields such as medicine, agriculture, water purification, fire engineering and so on. The present study was designed to evaluate toxicity of different NS formulations (namely, S1-S6) synthesized with different cross-linking agents such as carbonyl diimidazole, pyromellitic dianhydride and hexamethylene diisocynate; and preparation methods in experimental animals. Acute and repeated dose toxicity studies of formulations were carried out as per OECD guidelines 423 and 407, respectively. For acute toxicity study, formulations were administered to female rats at doses of 300 and 2000 mg/kg orally. The general behaviour of the rats was continuously monitored for 1 h after dosing, periodically during the first 24 h and daily thereafter for a total of 14 days. On day 14, animals were fasted overnight, weighed, and sacrificed. After sacrification, animals were subjected to necropsy. For repeated dose toxicity study, rats of either sex were orally administered with formulations at the dose of 300 mg/kg per day for a period of 28 days. The maximally tolerated dose of all formulations was found to be 2000 mg/kg. Repeated administration of formulations for 28 days did not show any signif...Continue Reading

References

Nov 11, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shankar SwaminathanRoberta Cavalli
Jan 13, 2012·Pharmaceutical Development and Technology·Satyen TorneRoberta Cavalli
Jul 11, 2012·Toxicology International·Y A Kulkarni, A Veeranjaneyulu
Dec 18, 2012·Beilstein Journal of Organic Chemistry·Francesco TrottaRoberta Cavalli
Aug 21, 2013·International Journal of Pharmaceutics·Pravin ShendeFabrizio Caldera

❮ Previous
Next ❯

Citations

Jan 23, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shankar SwaminathanFrancesco Trotta
Aug 16, 2015·International Journal of Pharmaceutics·Kiran DeshmukhRoberta Cavalli
Jul 28, 2016·Expert Opinion on Drug Delivery·Valentina VenutiFrancesco Trotta
Sep 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kiran DeshmukhRoberta Cavalli
Oct 21, 2016·AAPS PharmSciTech·Monica R P Rao, Chaitanya Shirsath
Jun 25, 2017·International Journal of Pharmaceutics·Fabrizio CalderaFrancesco Trotta
Feb 7, 2018·BMC Complementary and Alternative Medicine·Nashwan Abdullah Al-AfifiAnand Ramanathan
May 7, 2020·Advanced Pharmaceutical Bulletin·Dipak Dilip Gadade, Sanjay Sudhakar Pekamwar
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monica ArgenzianoRoberta Cavalli
Jun 15, 2019·Journal of Materials Science. Materials in Medicine·Atul P SherjePravin Shende
May 20, 2020·Polymers·Ilona KrabicováFrancesco Trotta
Jul 30, 2019·Frontiers in Pharmacology·Nausicaa ClementeChiara Dianzani
Sep 12, 2020·International Journal of Pharmaceutics·Adrián MatencioJosé Manuel López-Nicolás
Sep 21, 2020·International Journal of Pharmaceutics·Silvia Lucia AppletonRoberta Cavalli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM
Olubanke O OgunlanaAfolabi A Akindahunsi
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
G B SinghS Singh
© 2022 Meta ULC. All rights reserved