Acute and Sub-Acute Toxicity Evaluation of the Methanolic Extract of Alstonia scholaris Stem Bark

Medical Sciences : Open Access Journal
Idris BelloMohd Zaini Asmawi

Abstract

Alstonia scholaris has been used by traditional medicine practitioners since the medieval ages for the treatment of diseases. The aim of this research was to evaluate the acute and sub-acute oral toxicity of its methanolic extract. The acute toxicity test was conducted using Sprague Dawley (SD) rats. The methanolic extract of Alstonia scholaris stem bark (ASME) was administrated in a single dose of 2000 mg/kg via oral gavage; and the animals were observed for any behavioral changes or mortality. In the sub-acute toxicity study, SD rats received three doses of ASME (250, 500 and 1000 mg/kg) for 28 days via oral gavage. During these 28 days of treatment, the rats were observed weekly for toxicity symptoms. Following the 28-day treatment, the rats were sacrificed for hematological, biochemical and histopathology studies. In the acute toxicity study, Alstonia scholaris was found to be non-toxic at a dose of 2000 mg/kg b.w. In the sub-acute toxicity study, significant variations in body weight, hematological and biochemical parameters were observed in the experimental groups at the dose of 500 and 1000 mg/kg with the death of two female rats being recorded at the highest dose (1000 mg/kg b.w.). Histopathological studies revealed sli...Continue Reading

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Citations

Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Jéssica Maurino Dos SantosKely de Picoli Souza
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hermione T ManekengVictor Kuete
Nov 20, 2020·Drug and Chemical Toxicology·Pallavi ShirsatSachin Tembhurne
Jul 13, 2021·Journal of Tropical Medicine·Gebrehiwot Kiros GebremariamTsgab Gebrecherkos Girmay

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